Central vasopressin V1a receptors modulate neural processing in mothers facing intruder threat to pups.
Central vasopressin V1a receptors modulate neural processing in mothers facing intruder threat to pups.
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DOI：
10.1016/j.neuropharm.2009.06.023
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发表时间：
2010-01
影响因子：
4.7
通讯作者：
Febo M
中科院分区：
文献类型：
--
作者：
Caffrey MK;Nephew BC;Febo M
大鼠大脑中的加压素V1 a受体已经被研究了它们在调节攻击性和焦虑中的作用。在目前的研究中，血氧水平依赖（BOLD）功能磁共振成像被用来测试是否V1 a受体调节母体大脑中的神经处理时，母鼠暴露于男性入侵者。在成像前90-120分钟，向初产雌性动物侧脑室（ICV）注射溶剂或V1 a受体拮抗剂（[脱氨基-Pen 1，O-Me-Try，Arg 8]-加压素，125 ng/10 μL）。在功能磁共振成像，清醒的母鼠提出了一个男性入侵者的威胁，小狗使用一个专门的腔室，其中包含单独的隔间小狗和男性入侵者。我们的研究结果表明，激活体素的数量减少，在皮质杏仁核与V1 a受体阻断，而增加，观察到在前嗅核和其他领域。V1 a拮抗剂治疗的大坝表现出显着更大的BOLD反应，在前嗅核，边缘前额叶皮层，味觉皮层，体感皮层，无名质时，提出了一个新的男性入侵者。BOLD反应在杏仁核皮质和下丘脑腹内侧减少。V1 a受体敏感区在嗅觉、味觉和触觉的加工以及情绪反应中发挥作用。因此，目前的功能性磁共振成像数据的一个解释是，加压素，通过V1 a受体，可以调节感觉处理，并可能协调这种效果与变化的内脏活动在初始阶段的母亲的侵略性动机和/或焦虑反应。
Vasopressin V1a receptors in the rat brain have been studied for their role in modulating aggression and anxiety. In the current study blood-oxygen-level-dependent (BOLD) functional MRI was used to test whether V1a receptors modulate neural processing in the maternal brain when dams are exposed to a male intruder. Primiparous females were given an intracerebroventricular (ICV) injection of vehicle or V1a receptor antagonist ([deamino-Pen1, O-Me-Try, Arg8]-Vasopressin, 125 ng/10 μL) 90-120 minutes before imaging. During fMRI, awake dams were presented with a male intruder threat to pups using a specialized chamber that contained separate compartments for pups and a male intruder. Our results indicate that the number of activated voxels was reduced in the cortical amygdala with V1a receptor blockade, while an increase was observed in the anterior olfactory nucleus and other areas. Dams treated with V1a antagonist showed significantly greater BOLD responses in the anterior olfactory nucleus, infralimbic prefrontal cortex, gustatory cortex, somatosensory cortex, and substantia innominata when presented with a novel male intruder. BOLD responses were reduced in the cortical amygdala and ventromedial hypothalamus. The V1a receptor sensitive areas play roles in the processing of smell, taste and touch and emotional reactivity. Thus one interpretation of the present fMRI data is that vasopressin, acting through V1a receptors, may modulate sensory processing and perhaps coordinate this effect with changes in visceromotor activity during the initial stages of maternal aggressive motivation and/or anxiogenic responses.
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DOI：
10.1111/j.1749-6632.1992.tb34382.x
发表时间：
1992-06-12
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
FERRIS, CF;FOOTE, KB;INSEL, TR
通讯作者：
INSEL, TR
DOI：
10.1073/pnas.0807412105
发表时间：
2008-11-04
影响因子：
11.1
作者：
Bosch, Oliver J.;Neumann, Inga D.
通讯作者：
Neumann, Inga D.
影响因子：
64.8
作者：
Lim, MM;Wang, ZX;Young, LJ
通讯作者：
Young, LJ
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
3.7
作者：
BRIDGES, RS;MANN, PE
通讯作者：
MANN, PE