Neural Correlates of Theory of Mind in Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, and the Comorbid Condition.
Neural Correlates of Theory of Mind in Autism Spectrum Disorder, Attention-Deficit/Hyperactivity Disorder, and the Comorbid Condition.
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DOI：
10.3389/fpsyt.2020.544482
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发表时间：
2020
影响因子：
4.7
通讯作者：
Simonoff E
中科院分区：
文献类型：
--
作者：
Ilzarbe D;Lukito S;Moessnang C;O'Daly OG;Lythgoe DJ;Murphy CM;Ashwood K;Stoencheva V;Rubia K;Simonoff E
据报道，注意力缺陷/多动障碍(ADHD)和自闭症谱系障碍(ASD)存在心理理论(Tom)或心智障碍，但支持这些明显共同缺陷的机制相对未知。83名年轻成年男性，19名单独患有ASD，21名单独患有ADHD，18名患有ASD和ADHD双重诊断的人，以及25名典型的发育中(TD)对照组完成了Frith-Happé动画三角TOM任务的功能磁共振成像版本。我们使用全脑和感兴趣区的大脑激活分析和功能连接分析，比较了TOM和两种非TOM情况下的神经功能，即随机运动和目标定向运动。这两组人的TOM任务表现相当。在TOM期间，所有三个临床组都缺乏TD对照组显示的右侧顶叶皮质的局部连接性增加，这是一个关键的脑化区域，ASD组和合并ADHD组的激活模式相对于ADHD都有不同程度的增加。两组ASD患者的右下外侧前额叶和后扣带回皮质之间的连通性也降低，这可能反映了一种非典型的信息传递到精神化网络。相反，与TD对照组相比，两组ADHD患者的内侧前额叶和左侧顶叶皮质之间的连通性降低。因此，尽管在这三种疾病中，非典型脑功能的复杂模式支撑着TOM，但TOM期间的一些神经功能异常与ASD相关，并与ADHD相关的神经功能异常看起来是不同的，共病组显示出在每种情况下发现的综合异常。
Theory of mind (ToM) or mentalizing difficulties is reported in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), but the mechanism underpinning these apparently shared deficits is relatively unknown. Eighty-three young adult males, 19 with ASD alone, 21 with ADHD alone, 18 with dual diagnosis of ASD and ADHD, and 25 typically developing (TD) controls completed the functional magnetic resonance imaging version of the Frith-Happé animated-triangle ToM task. We compared neural function during ToM with two non-ToM conditions, random and goal directed motions, using whole-brain and region-of-interest analysis of brain activation and functional connectivity analyses. The groups showed comparable ToM task performance. All three clinical groups lacked local connectivity increase shown by TD controls during ToM in the right temporoparietal cortex, a key mentalizing region, with a differentially increased activation pattern in both ASD and comorbid groups relative to ADHD. Both ASD groups also showed reduced connectivity between right inferior lateral prefrontal and posterior cingulate cortices that could reflect an atypical information transmission to the mentalizing network. In contrast, with mentalizing both ADHD groups showed decreasing connectivity between the medial prefrontal and left temporoparietal cortices when compared to TD controls. Therefore, despite the complex pattern of atypical brain function underpinning ToM across the three disorders, some neurofunctional abnormalities during ToM are associated with ASD and appeared differentiable from those associated with ADHD, with the comorbid group displaying combined abnormalities found in each condition.
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影响因子：
3.1
作者：
Abdel-Hamid, Mona;Niklewski, Franziska;Kis, Bernhard
通讯作者：
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Margulies DS
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影响因子：
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25.8
作者：
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影响因子：
6.6
作者：
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