Mentalizing in male schizophrenia patients is compromised by virtue of dysfunctional connectivity between task-positive and task-negative networks.
Mentalizing in male schizophrenia patients is compromised by virtue of dysfunctional connectivity between task-positive and task-negative networks.
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由于任务阳性和任务阴性网络之间的连通性功能失调，因此在男性精神分裂症患者中进行了心理化。
DOI：
10.1016/j.schres.2012.06.023
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发表时间：
2012-09
影响因子：
4.5
通讯作者：
Malhi, Gin S.
中科院分区：
文献类型：
--
作者：
Das, Pritha;Calhoun, Vince;Malhi, Gin S.
关键词：
精神分裂症可以被概念化为额颞（FT）和/或默认模式（DM）网络内的功能连接障碍。最近的证据表明，这些大型神经网络之间的功能失调也可能导致这种疾病，并且精神分裂症患者的心智化或“心理理论”（ToM）能力明显受损。因此，在这项研究中，我们研究了功能网络连接（FNC）受损是否会导致精神分裂症患者的心理能力受损。功能性磁共振成像数据是从 20 名男性精神分裂症患者和 19 名匹配的健康对照者身上获取的，同时执行一项众所周知的 ToM 任务。研究表明，与非 ToM 相比，与健康受试者相比，ToM 的参与导致患者外侧 FT 和岛叶网络的神经活动减少。研究结果还表明，与健康受试者相比，无论任务如何（ToM/非 ToM），患者的 DM 和内侧 FT 网络受到的抑制较小。此外，FNC 分析表明，与对照组相比，患者的任务阳性网络（外侧 FT 和岛叶）和任务阴性网络（内侧 FT、后 DM）之间的功能连接程度显着降低。值得注意的是，外侧 FT 网络与内侧 FT 的功能连接强度与 ToM 任务调节的程度之间存在显着相关性，这表明男性精神分裂症患者的心智缺陷可能源于理解自我（内侧 FT）和他人（外侧 FT）精神状态的神经网络之间的沟通受损。
Schizophrenia can be conceptualized as a disorder of functional connectivity within the fronto-temporal (FT) and/or default-mode (DM) networks. Recent evidence suggests that dysfunctional integration between these large neural networks may also contribute to the illness, and that the ability to mentalize or have a ‘theory of mind’ (ToM) is discernibly impaired in patients with schizophrenia. Hence in this study, we examined whether impaired functional network connectivity (FNC) contributes to a compromise in the ability to mentalize in patients with schizophrenia. Functional magnetic resonance imaging data were acquired from 20 male schizophrenia patients and 19 matched healthy controls whilst performing a well-known ToM task. The study revealed that relative to non-ToM the engagement of ToM produced reduced neural activity in the lateral FT and insula networks in patients, as compared to healthy subjects. The findings also indicated that in comparison to healthy subjects the DM and medial FT networks are less suppressed in patients irrespective of the task (ToM/non-ToM). Further, FNC analyses showed that the degree of functional connectivity between task-positive (lateral FT and insula) and task-negative (medial FT, posterior DM) networks was significantly reduced in patients as compared to controls. Of note, a significant correlation between the functional connectivity strength of the lateral FT network with the medial FT and the degree to which this is modulated by the ToM task, suggest that mentalizing deficits in male schizophrenia patients may stem from impaired communication between neural networks that comprehend the mental states of self (medial FT) and others (lateral FT).
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
1.7
作者：
Harrington, Leigh;Siegert, Richard J;McClure, John
通讯作者：
McClure, John
影响因子：
5.7
作者：
Calhoun, VD;Adali, T;Pearlson, GD
通讯作者：
Pearlson, GD
影响因子：
6.6
作者：
Bluhm, Robyn L.;Miller, Jodi;Williamson, Peter
通讯作者：
Williamson, Peter
DOI：
10.1073/pnas.0935845100
发表时间：
2003-04-29
影响因子：
11.1
作者：
Carr, L;Iacoboni, M;Lenzi, GL
通讯作者：
Lenzi, GL