Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence
Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence
复制标题
虐待后头发皮质醇减少介导童年中期和青春期的外化症状
DOI：
10.1111/jcpp.12700
复制
发表时间：
2017
影响因子：
7.6
通讯作者：
A. M.. . . Stalder
中科院分区：
文献类型：
--
作者：
von Klitzing;Sierau;Michel;A. M.. . . Stalder
儿童期虐待对生物系统的持久影响以及随之而来的精神病理学仍然不完全清楚。压力的长期影响可能反映在几个月的累积皮质醇分泌中，现在可以通过头发皮质醇浓度（HCC）进行量化。我们利用头发皮质醇分析的潜力，在受虐待和未受虐待的儿童和青少年的大样本中进行了第一次全面调查。方法参与者包括537名遭受虐待（n= 245）或无虐待历史的儿童和青少年（3-16岁; 272名女性）（n= 292）。受虐受试者从儿童保护服务（CPS;n= 95），青年精神病服务（n= 56），和社区（n= 94）。使用虐待分类系统对虐待进行编码，该系统借鉴了照顾者的访谈，并以CPS记录作为补充。照顾者和教师报告了儿童心理健康情况。HCC进行了评估，在第一个3厘米的hair segment.ResultsAnalyses一致支持，虐待相吻合的逐渐和剂量依赖性减少HCC从9至10年起，相对于nonmaltreated对照。这一模式在虐待和非虐待受试者之间的组比较（虐待9-16岁儿童的HCC减少27.6%）和虐待受试者的维度分析中一致，较低的HCC与更高的虐待慢性化和亚型数量相关。此外，两个组的比较和尺寸分析内虐待青年显示，相对肝癌减少介导的影响，虐待外化symptoms.ConclusionsFrom童年中期起，虐待符合皮质醇分泌的相对减少，这反过来，可能易患外化症状。
BackgroundThe enduring impact of childhood maltreatment on biological systems and ensuing psychopathology remains incompletely understood. Long‐term effects of stress may be reflected in cumulative cortisol secretion over several months, which is now quantifiable via hair cortisol concentrations (HCC). We conducted a first comprehensive investigation utilizing the potential of hair cortisol analysis in a large sample of maltreated and nonmaltreated children and adolescents.MethodParticipants included 537 children and adolescents (3–16 years; 272 females) with maltreatment (n= 245) or without maltreatment histories (n= 292). Maltreated subjects were recruited from child protection services (CPS;n= 95), youth psychiatric services (n= 56), and the community (n= 94). Maltreatment was coded using the Maltreatment Classification System drawing on caregiver interviews and complemented with CPS records. Caregivers and teachers reported on child mental health. HCC were assessed in the first 3 cm hair segment.ResultsAnalyses uniformly supported that maltreatment coincides with a gradual and dose‐dependent reduction in HCC from 9 to 10 years onwards relative to nonmaltreated controls. This pattern emerged consistently from both group comparisons between maltreated and nonmaltreated subjects (27.6% HCC reduction in maltreated 9–16‐year‐olds) and dimensional analyses within maltreated subjects, with lower HCC related to greater maltreatment chronicity and number of subtypes. Moreover, both group comparisons and dimensional analyses within maltreated youth revealed that relative HCC reduction mediates the effect of maltreatment on externalizing symptoms.ConclusionsFrom middle childhood onwards, maltreatment coincides with a relative reduction in cortisol secretion, which, in turn, may predispose to externalizing symptoms.
登录
查看更多内容
影响因子：
8.2
作者：
Susman, EJ
通讯作者：
Susman, EJ
影响因子：
5.1
作者：
Dozier, M;Manni, M;Levine, S
通讯作者：
Levine, S
影响因子：
3.7
作者：
Miller, Robert;Plessow, Franziska
通讯作者：
Plessow, Franziska
早期忽视和虐待可预测成人的昼夜皮质醇模式 对国际被收养者的研究
影响因子：
3.7
作者：
Esther J. M. Vegt;J. Ende;C. Kirschbaum;F. Verhulst;H. Tiemeier
通讯作者：
H. Tiemeier
影响因子：
3.7
作者：
Stalder, Tobias;Steudte, Susann;Kirschbaum, Clemens
通讯作者：
Kirschbaum, Clemens