Clinicoradiological Features in Progressive Supranuclear Palsy Comorbid with Argyrophilic Grains
Clinicoradiological Features in Progressive Supranuclear Palsy Comorbid with Argyrophilic Grains
复制标题
伴有嗜银颗粒的进行性核上性麻痹的临床放射学特征
DOI：
10.1002/mdc3.13455
复制
发表时间：
2022
影响因子：
4
通讯作者：
Hashizume Yoshio
中科院分区：
文献类型：
--
作者：
Sakurai Keita;Kaneda Daita;Morimoto Satoru;Uchida Yuto;Inui Shohei;Kimura Yasuyuki;Kato Takashi;Ito Kengo;Hashizume Yoshio
目的比较12例进行性核上性麻痹(PSPw/AG)和8例非进行性进行性核上性麻痹(PSPw/OAG)患者的临床放射学特征。方法从单一的脑库数据库中对病历和磁共振成像进行回顾性分析。结果除AGD外，两组在其他神经退行性病变方面均无差异。PSPw/AG患者的发病年龄和死亡年龄均高于PSPw/OAG患者(分别为77.9 ± 4.9vs.68.9 ± 5.9和87.0 ± 5.7vs.78.1 ± 5.0；P=0.003和P=0.002)。除了较晚出现的运动症状外，最初的遗忘症仅限于5例PSPw/AG患者。8例PSPw/AG患者既有特征性中脑萎缩，又有重度周围回萎缩。结论PSPw/AG患者的首发遗忘症和周围回萎缩可能是其特征。
BackgroundContrary to pure cases, the influence of comorbid argyrophilic grain disease (AGD) in progressive supranuclear palsy (PSP) has not been sufficiently evaluated.ObjectivesWe compared the clinicoradiological features of 12 patients with PSP with (PSPw/AG) and 8 patients without AGD (PSPw/oAG).MethodsMedical records and magnetic resonance imaging were checked retrospectively from a single brain bank database.ResultsOther than AGD, no differences were observed in any other neurodegenerative pathologies between the 2 groups. Ages at onset and deaths of patients with PSPw/AG were higher than those of patients with PSPw/oAG (77.9 ± 4.9 vs. 68.9 ± 5.9, and 87.0 ± 5.7 vs. 78.1 ± 5.0;P= 0.003 andP= 0.002, respectively). In addition to the later onset of motor symptoms, initial amnestic presentations were limited to 5 patients with PSPw/AG. Both characteristic midbrain atrophy and severe ambient gyrus atrophy were detected exclusively in 8 patients with PSPw/AG.ConclusionsInitial amnestic presentations and ambient gyrus atrophy may be characteristic of PSPw/AG.
登录
查看更多内容
[一名无神经体征的进行性核上性麻痹老年患者]。
DOI：
--
发表时间：
1997
期刊：
No to shinkei = Brain and nerve
影响因子：
--
作者：
K. Niizato;N. Kuroki;T. Arai;K. Kase;S. Iritani;K. Ikeda
通讯作者：
K. Ikeda
影响因子：
2.3
作者：
Sakamoto, Rieko;Tsuchiya, Kuniaki;Mimura, Masaru
通讯作者：
Mimura, Masaru
影响因子：
14.5
作者：
DANIEL, SE;DEBRUIN, VMS;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
12.7
作者：
Hattori, M;Hashizume, Y;Ojika, K
通讯作者：
Ojika, K
区分晚期阿尔茨海默病和其他边缘 Tau蛋白病的简单定量指数。
DOI：
10.3233/jad-210043
发表时间：
2021
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
K. Sakurai;D. Kaneda;S. Inui;Yuto Uchida;S. Morimoto;T. Nihashi;Takashi Kato;Kengo Ito;Y. Hashizume
通讯作者：
Y. Hashizume