Nanodisco balls: control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles.
Nanodisco balls: control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles.
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DOI：
10.1021/nn502730q
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发表时间：
2014-09-23
期刊：
影响因子：
17.1
通讯作者：
Cormode, David P.
中科院分区：
文献类型：
--
作者：
Chhour, Peter;Gallo, Nicolas;Cheheltani, Rabee;Williams, Dewight;Al-Zaki, Ajlan;Paik, Taejong;Nichol, Jessica L.;Tian, Zhicheng;Naha, Pratap C.;Witschey, Walter R.;Allcock, Harry R.;Murray, Christopher B.;Tsourkas, Andrew;Cormode, David P.
复杂结构的纳米颗粒可以具有独特的性质。球形纳米晶体的自组装是此类系统的高产率途径。在这项研究中，我们报告的聚合物和纳米晶体的自组装成聚集体，其中的纳米晶体的位置可以控制在表面或在核心。这些纳米球，当表面装饰有纳米晶体时，类似于迪斯科球，因此称为纳米迪斯科球。我们研究了这种表面负载现象的机制，发现它是Ca 2+依赖性的。我们还研究了是否过量的磷脂可以防止粘附。我们发现，表面负载发生与各种类型的纳米粒子，包括氧化铁纳米粒子，量子点，和纳米荧光粉，以及大小（10-30纳米）和形状。此外，表面负载发生在聚合物分子量（约30-3000 kDa）和磷脂碳尾长度的范围内。我们还表明，纳米晶体保持诊断活性后，加载到聚合物纳米球，即，在磁共振成像的情况下为氧化铁纳米颗粒提供对比度，并为量子点提供荧光。最后，我们证明了荧光标记的蛋白质模型药物可以通过表面负载的纳米球递送。我们提出了一个平台的造影剂输送，与不寻常的功能，有效载荷可以可控地定位到核心或表面。
Nanoparticles of complex architectures can have unique properties. Self-assembly of spherical nanocrystals is a high yielding route to such systems. In this study, we report the self-assembly of a polymer and nanocrystals into aggregates, where the location of the nanocrystals can be controlled to be either at the surface or in the core. These nanospheres, when surface decorated with nanocrystals, resemble disco balls, thus the term nanodisco balls. We studied the mechanism of this surface loading phenomenon and found it to be Ca2+ dependent. We also investigated whether excess phospholipids could prevent nanocrystal adherence. We found surface loading to occur with a variety of nanocrystal types including iron oxide nanoparticles, quantum dots, and nanophosphors, as well as sizes (10–30 nm) and shapes. Additionally, surface loading occurred over a range of polymer molecular weights (∼30–3000 kDa) and phospholipid carbon tail length. We also show that nanocrystals remain diagnostically active after loading onto the polymer nanospheres, i.e., providing contrast in the case of magnetic resonance imaging for iron oxide nanoparticles and fluorescence for quantum dots. Last, we demonstrated that a fluorescently labeled protein model drug can be delivered by surface loaded nanospheres. We present a platform for contrast media delivery, with the unusual feature that the payload can be controllably localized to the core or the surface.
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影响因子：
15
作者：
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通讯作者：
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影响因子：
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