Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study.
Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study.
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可卡因戒断的临床现象学和神经生物学：一项前瞻性住院患者研究。
DOI：
10.1176/ajp.148.12.1712
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Kleber,HD
中科院分区：
文献类型：
--
作者：
Satel,SL;Price,LH;Palumbo,JM;McDougle,CJ;Krystal,JH;Gawin,F;Charney,DS;Heninger,GR;Kleber,HD
本研究记录了突然停止可卡因使用后出现的症状和多巴胺能功能的变化，入院后，22例DSM-III-R可卡因依赖患者观察了3周的药物自由。每天完成患者评定的Ribicoff戒断量表，症状评定量表，躯体症状量表，患者评定的焦虑量表，贝克抑郁量表和视觉模拟量表的16个主观状态，护士评定13例患者的整体焦虑和抑郁的短期临床评定量表的项目。每周三次采集系列血液样本，测量患者的催乳素、生长激素（GH）和高香草酸（HVA）水平。他们的催乳素和GH值与匹配的正常subjects.ResultsA共62个主观症状变量进行了评价。基线时，症状评分轻度升高。第3周时，28个变量较基线显著降低，另外6个变量几乎显著降低。护士评定的焦虑和抑郁也发生了变化，但变化更大。随着时间的推移，血浆催乳素较基线小幅但显著增加，但GH或HVA无显著变化。患者的催乳素和GH值没有显着差异，从那些正常subjects.ConclusionsThese研究结果表明，住院后停止简单的可卡因成瘾的症状是相对温和的，线性下降的第一个月。中枢多巴胺功能失调的证据有限。研究结果不支持在此类患者的住院治疗中常规使用药物。
ObjectiveThis study was undertaken to document symptoms and changes in dopaminergic function emerging after abrupt cessation of cocaine use.MethodAfter admission, 22 patients with DSM-III-R cocaine dependence were observed drug free for 3 weeks. The patient-rated Ribicoff Abstinence Rating Scale, Symptom Rating Scale, Physical Symptom Scale, Patient Rated Anxiety Scale, Beck Depression Inventory, and visual analogue scales for 16 subjective states were completed daily, and nurses rated 13 patients with the global anxiety and depression items of the Short Clinical Rating Scale. Serial blood samples were obtained three times weekly, and the patients' levels of prolactin, growth hormone (GH), and homovanillic acid (HVA) were measured. Their prolactin and GH values were compared with those of matched normal subjects.ResultsA total of 62 subjective symptom variables were evaluated. At baseline, the symptom ratings were mildly elevated. At 3 weeks there were significant decreases from baseline in 28 variables and nearly significant decreases in six additional variables. Nurse-rated anxiety and depression also changed, but in a more variable pattern. There was a small but significant increase from baseline over time in plasma prolactin, but there were no significant changes in GH or HVA. The patients' prolactin and GH values did not differ from those of the normal subjects.ConclusionsThese findings suggest that symptoms after inpatient cessation of uncomplicated cocaine addiction are relatively mild and decrease linearly over the first month. Evidence of dysregulated central dopamine function was limited. The findings do not support routine use of pharmacological agents in the inpatient management of such patients.
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可卡因的精神药理学
DOI：
--
发表时间：
1984
期刊：
影响因子：
--
作者：
M. Gold;K. Verebey
通讯作者：
K. Verebey
评估阿片依赖的存在和严重程度
DOI：
10.1002/cpt1974164653
发表时间：
1974
期刊：
Clinical pharmacology and therapy
影响因子：
--
作者：
Richard I. H. Wang;Richard L. Wiesen;Sofian Lamid;Byung L. Roh
通讯作者：
Byung L. Roh
可卡因和性功能障碍：古柯妈妈的诅咒。
影响因子：
2.8
作者：
R. K. Siegel
通讯作者：
R. K. Siegel
可乐定在美沙酮突然戒断中的临床应用。
影响因子：
--
作者：
Charney,DS;Sternberg,DE;Kleber,HD;Heninger,GR;RedmondJr,DE
通讯作者：
RedmondJr,DE
可卡因戒断期间的垂体前叶、肾上腺和性腺激素。
DOI：
10.1176/ajp.145.9.1094
发表时间：
1988
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Mendelson,JH;Teoh,SK;Lange,U;Mello,NK;Weiss,R;Skupny,A;Ellingboe,J
通讯作者：
Ellingboe,J