Stress in obstructive sleep apnea.
Stress in obstructive sleep apnea.
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DOI：
10.1038/s41598-021-91996-5
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发表时间：
2021-06-16
影响因子：
4.6
通讯作者：
Macey PM
中科院分区：
文献类型：
--
作者：
Wong JL;Martinez F;Aguila AP;Pal A;Aysola RS;Henderson LA;Macey PM
患有阻塞性睡眠呼吸暂停（OSA）的人通常有包括抑郁和焦虑在内的心理症状，这些症状通常通过抗抑郁或抗焦虑干预来治疗。心理应激是一种相关症状，干预目标不同，也可能改善精神状态，但在OSA中没有很好的表征。因此，我们的目的是描述压力与其他心理症状的关系。我们对103人进行了前瞻性横断面研究，其中44人未经治疗的OSA（平均±s.d）。年龄：51.2±13.9岁，女/男13/31)，健康对照57例（年龄：46.3±13.8岁，女/男34/23）。我们测量了压力（感知压力量表；PSS）、白天过度嗜睡（Epworth嗜睡量表；ESS）、抑郁症状（患者健康问卷；PHQ-9）和焦虑症状（一般焦虑障碍；GAD-7）。我们将组均值与独立样本t检验进行比较，并计算变量之间的相关性。OSA组的平均症状水平高于对照组，包括PSS （Mean±s.d）。： OSA = 15.3±6.9，对照组= 11.4±5.5；P = 0.002), GAD-7(阻塞性睡眠呼吸暂停综合症= 4.8±5.0,控制= 2.1±3.9;P = 0.02), phq - 9(阻塞性睡眠呼吸暂停综合症= 6.9±6.1,控制= 2.6±3.8;P = 0.003)和ESS(阻塞性睡眠呼吸暂停综合症= 8.1±5.3,控制= 5.0±3.3;P = 0.03)。男性与对照组也存在类似的差异，但女性仅在PHQ-9和ESS上存在显著差异，PSS和GAD-7无显著差异。PSS与GAD-7、PHQ-9呈正相关（R = 0.62 ~ 0.89），与ESS呈正相关（R = 0.62 ~ 0.89）。感知压力在OSA中较高，且与焦虑和抑郁症状密切相关。研究结果支持测试压力减轻对阻塞性睡眠呼吸暂停的影响。
People with obstructive sleep apnea (OSA) often have psychological symptoms including depression and anxiety, which are commonly treated with anti-depression or anti-anxiety interventions. Psychological stress is a related symptom with different intervention targets that may also improve mental state, but this symptom is not well characterized in OSA. We therefore aimed to describe stress in relation to other psychological symptoms. We performed a prospective cross-sectional study of 103 people, 44 untreated OSA (mean ± s.d. age: 51.2 ± 13.9 years, female/male 13/31) and 57 healthy control participants (age: 46.3 ± 13.8 years, female/male 34/23). We measured stress (Perceived Stress Scale; PSS), excessive daytime sleepiness (Epworth Sleepiness Scale; ESS), depressive symptoms (Patient Health Questionnaire; PHQ-9), and anxiety symptoms (General Anxiety Disorder; GAD-7). We compared group means with independent samples t-tests and calculated correlations between variables. Mean symptom levels were higher in OSA than control, including PSS (mean ± s.d.: OSA = 15.3 ± 6.9, control = 11.4 ± 5.5; P = 0.002), GAD-7 (OSA = 4.8 ± 5.0, control = 2.1 ± 3.9; P = 0.02), PHQ-9 (OSA = 6.9 ± 6.1, control = 2.6 ± 3.8; P = 0.003) and ESS (OSA = 8.1 ± 5.3, control = 5.0 ± 3.3; P = 0.03). Similar OSA-vs-control differences appeared in males, but females only showed significant differences in PHQ-9 and ESS, not PSS or GAD-7. PSS correlated strongly with GAD-7 and PHQ-9 across groups (R = 0.62–0.89), and moderately with ESS. Perceived stress is high in OSA, and closely related to anxiety and depressive symptoms. The findings support testing stress reduction in OSA.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1183/13993003.02421-2017
发表时间：
2018-03
期刊：
The European respiratory journal
影响因子：
--
作者：
Huang T;Lin BM;Markt SC;Stampfer MJ;Laden F;Hu FB;Tworoger SS;Redline S
通讯作者：
Redline S
影响因子：
--
作者：
Haddock, Nicole;Wells, Mary Ellen
通讯作者：
Wells, Mary Ellen
影响因子：
4.7
作者：
Bilyukov, Radoslav G.;Nikolov, Martin S.;Milanova, Vihra K.
通讯作者：
Milanova, Vihra K.
影响因子：
5.9
作者：
GUILLEMINAULT, C
通讯作者：
GUILLEMINAULT, C