Genome sequence of Aedes aegypti, a major arbovirus vector.
Genome sequence of Aedes aegypti, a major arbovirus vector.
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DOI：
10.1126/science.1138878
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发表时间：
2007-06-22
期刊：
影响因子：
--
通讯作者：
Severson DW
中科院分区：
文献类型：
--
作者：
Nene V;Wortman JR;Lawson D;Haas B;Kodira C;Tu ZJ;Loftus B;Xi Z;Megy K;Grabherr M;Ren Q;Zdobnov EM;Lobo NF;Campbell KS;Brown SE;Bonaldo MF;Zhu J;Sinkins SP;Hogenkamp DG;Amedeo P;Arensburger P;Atkinson PW;Bidwell S;Biedler J;Birney E;Bruggner RV;Costas J;Coy MR;Crabtree J;Crawford M;Debruyn B;Decaprio D;Eiglmeier K;Eisenstadt E;El-Dorry H;Gelbart WM;Gomes SL;Hammond M;Hannick LI;Hogan JR;Holmes MH;Jaffe D;Johnston JS;Kennedy RC;Koo H;Kravitz S;Kriventseva EV;Kulp D;Labutti K;Lee E;Li S;Lovin DD;Mao C;Mauceli E;Menck CF;Miller JR;Montgomery P;Mori A;Nascimento AL;Naveira HF;Nusbaum C;O'leary S;Orvis J;Pertea M;Quesneville H;Reidenbach KR;Rogers YH;Roth CW;Schneider JR;Schatz M;Shumway M;Stanke M;Stinson EO;Tubio JM;Vanzee JP;Verjovski-Almeida S;Werner D;White O;Wyder S;Zeng Q;Zhao Q;Zhao Y;Hill CA;Raikhel AS;Soares MB;Knudson DL;Lee NH;Galagan J;Salzberg SL;Paulsen IT;Dimopoulos G;Collins FH;Birren B;Fraser-Liggett CM;Severson DW
我们提供了埃及伊蚊基因组的草稿序列，埃及伊蚊是黄热病和登革热的主要媒介，它的大小约为1.38GBP，是疟疾媒介冈比亚按蚊基因组的5倍。埃及伊蚊近50%的基因组由转座子组成。这使得冈比亚按蚊和黑腹果蝇的平均基因长度和基因间隔区的大小增加了约4-6倍。然而，三种昆虫之间的染色体同步性总体上是保持的，尽管蚊子物种之间的同源基因序列的保守性比它们与果蝇之间的保守性要高(~2倍)。三种方法已经为埃及伊蚊预测的15,419个蛋白质编码基因中的80%提供了转录证据。冈比亚按蚊气味结合、细胞色素P450和角质层结构域编码基因的增加表明，这些蛋白家族的成员支撑了它们之间的一些生物学差异。
We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at ~1.38 Gbp is ~5-fold larger in size than the genome of the malaria vector, Anopheles gambiae. Nearly 50% of the Aedes aegypti genome consists of transposable elements. These contribute to a ~4-6 fold increase in average gene length and the size of intergenic regions relative to Anopheles gambiae and Drosophila melanogaster. Nevertheless, chromosomal synteny is generally maintained between all three insects although conservation of orthologous gene order is higher (~2-fold) between the mosquito species than between either of them and fruit fly. Three methods have provided transcriptional evidence for 80% of the 15,419 predicted protein coding genes in Aedes aegypti. An increase in genes encoding odorant binding, cytochrome P450 and cuticle domains relative to Anopheles gambiae suggests that members of these protein families underpin some of the biological differences between them.
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DOI：
10.1053/j.spid.2006.04.009
发表时间：
2006-04-01
期刊：
Seminars in pediatric infectious diseases
影响因子：
--
作者：
Ligon, B Lee
通讯作者：
Ligon, B Lee
影响因子：
14.9
作者：
Ren, QH;Kang, KH;Paulsen, IT
通讯作者：
Paulsen, IT
影响因子：
4.8
作者：
Shin, Sang Woon;Bian, Guowu;Raikhel, Alexander S.
通讯作者：
Raikhel, Alexander S.
影响因子：
7
作者：
Jaffe, DB;Butler, J;Lander, ES
通讯作者：
Lander, ES
影响因子：
2.6
作者：
Severson, DW;Meece, JK;Morlais, I
通讯作者：
Morlais, I