Neurobiology of the crustacean swimmeret system.
Neurobiology of the crustacean swimmeret system.
复制标题
甲壳类游泳系统的神经生物学。
DOI：
10.1016/j.pneurobio.2012.01.002
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发表时间：
2012-02
影响因子：
6.7
通讯作者：
Smarandache-Wellmann, Carmen
中科院分区：
文献类型：
--
作者：
Mulloney, Brian;Smarandache-Wellmann, Carmen
甲壳类动物的泳肢系统包括一组分布式的局部回路，它们单独控制一个关节肢的运动。这些模块化的局部回路成对出现在每个节段神经节中，并且通常同步操作以在不同的身体节段上产生平稳协调的肢体运动周期。该系统为协调的神经机制的计算和实验研究提供了特殊的机会，因为：该系统将在体外表达周期性运动模式，该模式通常在向前游泳期间驱动swimmeret运动的周期。B.编码正常协调所必需和足够的信息的节间神经元已经被识别出来，它们的活动可以被记录下来。C.整合这种协调信息并调整每个游泳池阶段的局部连合神经元是已知的。D.协调神经元和这些连合神经元之间的突触连接的完整集合已经被描述。e.每个局部模式生成回路上的突触连接已经被发现，通过这些突触连接，协调信息调整了回路的相位。这些因素使得第一次详细，全面的细胞和突触解释这个神经回路如何产生有效的，行为上重要的输出成为可能。本文是第一次全面审查系统的神经解剖学和神经生理学，其本地和节段间的电路，其递质药理学，其神经调节控制机制，以及其与其他运动系统的相互作用。这些主题中的每一个都被详细地涵盖，试图提供一个完整的文献综述，作为新研究的基础。一系列的假设，已经提出了考虑到系统的属性进行了严格审查，其有效性的实验测试的背景下。
The crustacean swimmeret system includes a distributed set of local circuits that individually control movements of one jointed limb. These modular local circuits occur in pairs in each segmental ganglion, and normally operate synchronously to produce smoothly coordinated cycles of limb movements on different body segments. The system presents exceptional opportunities for computational and experimental investigation of neural mechanisms of coordination because: a. The system will express in vitro the periodic motor pattern that normally drives cycles of swimmeret movements during forward swimming. b. The intersegmental neurons which encode information that is necessary and sufficient for normal coordination have been identified, and their activity can be recorded. c. The local commissural neurons that integrate this coordinating information and tune the phase of each swimmeret are known. d. The complete set of synaptic connections between coordinating neurons and these commissural neurons have been described. e. The synaptic connections onto each local pattern-generating circuit through which coordinating information tunes the circuit's phase have been discovered. These factors make possible for the first time a detailed, comprehensive cellular and synaptic explanation of how this neural circuit produces an effective, behaviorally-significant output. This paper is the first comprehensive review of the system's neuroanatomy and neurophysiology, its local and intersegmental circuitry, its transmitter pharmacology, its neuromodulatory control mechanisms, and its interactions with other motor systems. Each of these topics is covered in detail in an attempt to provide a complete review of the literature as a foundation for new research. The series of hypotheses that have been proposed to account for the system's properties are reviewed critically in the context of experimental tests of their validity.
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影响因子：
5.5
作者：
BARKER, DL;KRAVITZ, EA;HERBERT, E
通讯作者：
HERBERT, E
影响因子：
2.5
作者：
BRAUN, G;MULLONEY, B
通讯作者：
MULLONEY, B
影响因子：
2.5
作者：
CATTAERT, D;ARAQUE, A;CLARAC, F
通讯作者：
CLARAC, F
影响因子：
2.5
作者：
Ayali, A;Johnson, BR;Harris-Warrick, RM
通讯作者：
Harris-Warrick, RM
影响因子：
2.5
作者：
ACEVEDO, LD;HALL, WM;MULLONEY, B
通讯作者：
MULLONEY, B