The Neurotransmitters Involved in Drosophila Alcohol-Induced Behaviors.
The Neurotransmitters Involved in Drosophila Alcohol-Induced Behaviors.
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DOI：
10.3389/fnbeh.2020.607700
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发表时间：
2020
影响因子：
3
通讯作者：
Rothenfluh A
中科院分区：
文献类型：
--
作者：
Chvilicek MM;Titos I;Rothenfluh A
酒精是一种被广泛使用和滥用的物质，对人类健康和安全产生了许多负面影响。从历史上看，酒精广泛的、非特异性的神经生物学效应使得对人类的研究成为一个挑战。因此，模式生物是揭示酒精作用机制及其对行为的后续影响的关键工具。黑腹果蝇在基因上是温顺的，表现出大量的行为，这使它成为研究酒精反应的神经生物学的一个特别好的候选者。除了在实验上易于接受外，果蝇还具有很高的面孔和机制有效性：它们与酒精相关的行为与人类和其他哺乳动物物种非常一致，并且它们共享许多保守的神经递质和信号通路。果蝇在酒精研究方面有着悠久的历史，近年来，随着工具的发展，果蝇的神经递质被操纵，这一研究得到了加强。通过诸如GAL4/UAS系统和CRISPR/Cas9诱变等技术的进步，对神经元小子集中特定神经递质的研究变得越来越容易实现。在这篇综述中，我们描述了七种神经递质对苍蝇行为的贡献的最新进展，重点是它们在酒精反应中的作用：多巴胺、章鱼胺、酪胺、血清素、谷氨酸、GABA和乙酰胆碱。我们选择这些小分子神经递质是因为它们在哺乳动物中的保存和它们对行为的重要性。虽然像多巴胺和章鱼胺这样的神经递质对行为的贡献已经得到了重要的研究重点，但其他的，如谷氨酸、GABA和乙酰胆碱，仍然相对未被探索。在这里，我们总结了最近关于这七种神经递质及其在酒精行为反应中的作用的遗传和行为发现，强调了苍蝇作为人类酒精使用模型的适应性。
Alcohol is a widely used and abused substance with numerous negative consequences for human health and safety. Historically, alcohol's widespread, non-specific neurobiological effects have made it a challenge to study in humans. Therefore, model organisms are a critical tool for unraveling the mechanisms of alcohol action and subsequent effects on behavior. Drosophila melanogaster is genetically tractable and displays a vast behavioral repertoire, making it a particularly good candidate for examining the neurobiology of alcohol responses. In addition to being experimentally amenable, Drosophila have high face and mechanistic validity: their alcohol-related behaviors are remarkably consistent with humans and other mammalian species, and they share numerous conserved neurotransmitters and signaling pathways. Flies have a long history in alcohol research, which has been enhanced in recent years by the development of tools that allow for manipulating individual Drosophila neurotransmitters. Through advancements such as the GAL4/UAS system and CRISPR/Cas9 mutagenesis, investigation of specific neurotransmitters in small subsets of neurons has become ever more achievable. In this review, we describe recent progress in understanding the contribution of seven neurotransmitters to fly behavior, focusing on their roles in alcohol response: dopamine, octopamine, tyramine, serotonin, glutamate, GABA, and acetylcholine. We chose these small-molecule neurotransmitters due to their conservation in mammals and their importance for behavior. While neurotransmitters like dopamine and octopamine have received significant research emphasis regarding their contributions to behavior, others, like glutamate, GABA, and acetylcholine, remain relatively unexplored. Here, we summarize recent genetic and behavioral findings concerning these seven neurotransmitters and their roles in the behavioral response to alcohol, highlighting the fitness of the fly as a model for human alcohol use.
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影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
DOI：
10.1111/j.1530-0277.2007.00518.x
发表时间：
2007-11-01
影响因子：
3.2
作者：
Addicott, Merideth A.;Marsh-Richard, Dawn M.;Dougherty, Donald M.
通讯作者：
Dougherty, Donald M.
影响因子：
7.7
作者：
Bozler, Julianna;Kacsoh, Balint Z.;Bosco, Giovanni
通讯作者：
Bosco, Giovanni
影响因子：
5.3
作者：
Butts, Andrew R.;Ojelade, Shamsideen;Rothenfluh, Adrian
通讯作者：
Rothenfluh, Adrian
影响因子：
18.2
作者：
Allada R;Chung BY
通讯作者：
Chung BY