Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis.
Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis.
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挖掘纳米酶的生物活性，重塑微环境，保护软骨细胞，延缓骨关节炎。
DOI：
10.1016/j.bioactmat.2021.01.016
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发表时间：
2021-08
影响因子：
18.9
通讯作者：
Cai X
中科院分区：
文献类型：
--
作者：
Hou W;Ye C;Chen M;Gao W;Xie X;Wu J;Zhang K;Zhang W;Zheng Y;Cai X
Osteoarthritis (OA) is the main cause of disability in the elderly. Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease, and reduce the probability of joint replacement. However, there is to date no effective intervention for early and middle-stage OA. OA microenvironment mainly destroys the balance of oxidative stress, extracellular matrix synthesis and degradation of chondrocytes under the joint action of biological and mechanical factors. Herein, hollow Prussian blue nanozymes (HPBzymes) were designed via a modified hydrothermal template-free method. The aim of this study was to investigate the effects of HPBzymes on chondrocytes and the progression of OA. The intrinsic bioactivities of HPBzymes were excavated in vitro and in vivo, remodeling microenvironment for significantly protecting chondrocytes and delaying the progression of traumatic OA by inhibiting reactive oxygen species (ROS) and Rac1/nuclear factor kappa-B (NF-κB) signaling in a rat model. HPBzyme significantly diminished interleukin (IL)-1β-stimulated inflammation, extracellular matrix degradation, and apoptosis of human chondrocytes. HPBzyme attenuated the expression of Rac1 and the ROS levels and prevented the release and nuclear translocation of NF-κB. Deeply digging the intrinsic bioactivities of nanozyme with single component to remodel microenvironment is an effective strategy for ROS-associated chronic diseases. This study reveals that excavating the bioactivities of nanomedicine deserves attention for diagnosis and treatment of severe diseases. HPBzymes are synthesized via a modified hydrothermal template-free method. HPBzymes protectchondrocytes and delay the progression of traumatic OA.
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DOI：
10.3390/molecules23061414
发表时间：
2018-06-11
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Dacarro G;Taglietti A;Pallavicini P
通讯作者：
Pallavicini P
DOI：
10.1080/21691401.2019.1657877
发表时间：
2019-01-01
影响因子：
5.8
作者：
Chen, Xinxin;Zhang, Chengyong;Huo, Shousong
通讯作者：
Huo, Shousong
影响因子：
5.6
作者：
Ahmad N;Ansari MY;Haqqi TM
通讯作者：
Haqqi TM
影响因子：
7
作者：
Gerwin, N.;Bendele, A. M.;Carlson, C. S.
通讯作者：
Carlson, C. S.
影响因子：
13.8
作者：
Grosser T;Ricciotti E;FitzGerald GA
通讯作者：
FitzGerald GA