New gene evolution: little did we know.

New gene evolution: little did we know.
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DOI:
10.1146/annurev-genet-111212-133301
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发表时间:
2013
影响因子:
11.1
通讯作者:
Vibranovski MD
Vibranovski MD
中科院分区:
生物学1区
文献类型:
--
作者:
Long M;VanKuren NW;Chen S;Vibranovski MD

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Genes are perpetually added to and deleted from genomes during evolution. Thus, it is important to understand how new genes are formed and evolve as critical components of the genetic systems determining the biological diversity of life. Two decades of effort have shed light on the process of new gene origination, and have contributed to an emerging comprehensive picture of how new genes are added to genomes, ranging from the mechanisms that generate new gene structures to the presence of new genes in different organisms to the rates and patterns of new gene origination and the roles of new genes in phenotypic evolution. We review each of these aspects of new gene evolution, summarizing the main evidence for the origination and importance of new genes in evolution. We highlight findings showing that new genes rapidly change existing genetic systems that govern various molecular, cellular and phenotypic functions.
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