Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior.
Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior.
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DOI：
10.1016/j.physbeh.2011.05.012
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发表时间：
2011-09-01
影响因子：
2.9
通讯作者：
Tamashiro, Kellie L. K.
中科院分区：
文献类型：
--
作者：
Purcell, Ryan H.;Sun, Bo;Pass, Lauren L.;Power, Michael L.;Moran, Timothy H.;Tamashiro, Kellie L. K.
慢性可变的产前压力或母亲的高脂肪饮食会导致后代在产后第一周结束时体重明显增加，断奶后肥胖也会增加。然而，尚不清楚母体护理和饮食在这种表型的个体发生中起什么作用，以及幼鼠中已经建立的差异有何贡献。在本研究中，我们检查了母亲的行为和乳汁成分以及后代的摄入行为。我们的目的是更好地了解在妊娠和哺乳期间遭受产前应激和/或喂养高脂肪（HF）饮食的母鼠后代肥胖表型的发展。我们发现，在妊娠期和哺乳期维持高频饮食的母犬在产后第一周花费更多的时间来护理幼崽。此外，在一项独立的摄入测试中，产前应激母猪的后代在产后第 3 天（PND）消耗了更多的牛奶，而 HF 母猪的后代在 PND 7 消耗了更多的牛奶。与 PND 10-21 相比，HF 母乳的脂肪含量显着增加。这些结果共同表明，妊娠饮食或压力控制可以改变大鼠后代的发育环境，PND 3 证明了这一点。产后早期产妇护理、乳汁成分和幼仔消耗量的变化可能会导致产前应激或高脂肪饮食引起的体重和肥胖的长期变化。
Chronic variable prenatal stress or maternal high-fat diet results in offspring that are significantly heavier by the end of the first postnatal week with increased adiposity by weaning. It is unclear, however, what role maternal care and diet play in the ontogenesis of this phenotype and what contributions come from differences already established in the rat pups. In the present studies, we examined maternal behavior and milk composition as well as offspring ingestive behavior. Our aim was to better understand the development of the obese phenotype in offspring from dams subjected to prenatal stress and/or fed a high-fat (HF) diet during gestation and lactation. We found that dams maintained on a HF diet through gestation and lactation spent significantly more time nursing their pups during the first postnatal week. In addition, offspring of prenatal stress dams consumed more milk at postnatal day (PND) 3 and offspring of HF dams consume more milk on PND 7 in an independent ingestion test. Milk from HF dams showed a significant increase in fat content from PND 10-21. Together these results suggest that gestational dietary or stress manipulations can alter the rat offspring's developmental environment, evidence of which is apparent by PND 3. Alterations in maternal care, milk composition, and pup consumption during the early postnatal period may contribute to long-term changes in body weight and adiposity induced by maternal prenatal stress or high-fat diet.
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DOI：
10.1152/ajpregu.00379.2005
发表时间：
2006-01-01
影响因子：
2.8
作者：
Blumberg, S;Haba, D;Weller, A
通讯作者：
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影响因子：
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作者：
DelPrado, M;Delgado, G;Villalpando, S
通讯作者：
Villalpando, S