Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.

Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate.
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DOI:
10.1126/science.1194167
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发表时间:
2010-12-03
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Chourrout D
Chourrout D
中科院分区:
其他
文献类型:
--
作者:
Denoeud F;Henriet S;Mungpakdee S;Aury JM;Da Silva C;Brinkmann H;Mikhaleva J;Olsen LC;Jubin C;Cañestro C;Bouquet JM;Danks G;Poulain J;Campsteijn C;Adamski M;Cross I;Yadetie F;Muffato M;Louis A;Butcher S;Tsagkogeorga G;Konrad A;Singh S;Jensen MF;Huynh Cong E;Eikeseth-Otteraa H;Noel B;Anthouard V;Porcel BM;Kachouri-Lafond R;Nishino A;Ugolini M;Chourrout P;Nishida H;Aasland R;Huzurbazar S;Westhof E;Delsuc F;Lehrach H;Reinhardt R;Weissenbach J;Roy SW;Artiguenave F;Postlethwait JH;Manak JR;Thompson EM;Jaillon O;Du Pasquier L;Boudinot P;Liberles DA;Volff JN;Philippe H;Lenhard B;Roest Crollius H;Wincker P;Chourrout D

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动物的基因组像海绵和人类一样不同,显示了全球建筑的保护。在这里,我们发现包括转座子多样性、发育基因库、物理基因顺序和内含子-外显子组织在内的多种基因组特征在被囊脊椎动物中被打破,属于脊椎动物的姊妹类,并保留了脊索状的形态。动物基因组的祖先结构可能会被深度修改,因此可能在很大程度上是不适应的。因此,这种快速进化的动物谱系为基因组可塑性水平提供了独特的视角。它还阐明了与内含子增益机制一样的基本问题。
Genomes of animals as different as sponges and humans show conservation of global architecture. Here we show that multiple genomic features including transposon diversity, developmental gene repertoire, physical gene order, and intron-exon organization are shattered in the tunicate Oikopleura, belonging to the sister group of vertebrates and retaining chordate morphology. Ancestral architecture of animal genomes can be deeply modified and may therefore be largely nonadaptive. This rapidly evolving animal lineage thus offers unique perspectives on the level of genome plasticity. It also illuminates issues as fundamental as the mechanisms of intron gain.
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