Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients.
Opisthenar microvessel area as a sensitive predictive index of arterial stiffness in hypertensive patients.
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后鱼际微血管面积作为高血压患者动脉僵硬度的敏感预测指标。
DOI：
10.1038/s41598-021-02294-z
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发表时间：
2021-12-08
影响因子：
4.6
通讯作者：
Zhang YH
中科院分区：
文献类型：
--
作者：
Guo ZY;Chen C;Jin X;Zhao ZH;Cui L;Zhang YH
我们的目的是分析鱼际微血管面积（OMA，光学相干断层扫描（OCT）血管造影测量）是否与血压（BP），动脉硬度和OMA是否可以预测高血压（HTN）患者的动脉硬度。90例受试者的结果显示，与非HTN组（n = 54）相比，HTN组（n = 36）的血压、臂踝脉搏波速度（baPWV）和踝臂指数（ABI）显著升高，但OMA（对照组，冷刺激和热刺激，NT，CST，HST和差异，CSD，HSD）显著降低。女性组（n = 47）和男性组（n = 43）的NT、CST、HST和HSD与baPWV和ABI均呈负相关，但将受试者分为HTN和非HTN时，相关性不显著。Logistic回归分析显示，只有baPWV是HSD的显著危险因素（OR 19.7，95%CI 4.959-78.733，p < 0.0001），而年龄、BMI、吸烟、饮酒或运动状态与HSD无关（p > 0.05）。HSD的受试者操作特征分析分别为0.781、0.804、0.770。HSD < 9439.5 μm2预测高血压和动脉僵硬度（所有参与者的95%CI：baPWV，0.681-0.881，SBP，0.709-0.900，DBP，0.672-0.867，p < 0.001）。提示OMA是预测高血压人群动脉硬化的敏感指标。
We aimed to analyze whether opisthenar microvessel area (OMA, measured with Optical Coherence Tomography (OCT) angiography) was associated with blood pressure (BP), arterial stiffness and whether OMA can predict arterial stiffness in hypertensive (HTN) patients. Results from 90 participants showed that BP, brachial-ankle pulse wave velocity (baPWV) and ankle brachial index (ABI) were significantly higher but OMA (in control, with cold- and warm-stimulation, NT, CST, HST and the differences, CSD, HSD) were significantly reduced in HTN group (n = 36) compared to non-HTN (n = 54). NT, CST, HST and HSD showed negative correlations with baPWV and ABI in all participants, female (n = 47) and male group (n = 43), but the correlation was absent when the participants were divided into HTN and non-HTN. Logistic Regression analysis showed that only baPWV was a significant risk factor for HSD (OR 19.7, 95%CI 4.959–78.733, p < 0.0001) but not the age, BMI, smoking, drinking or exercise status (p > 0.05). Receiver Operating Characteristics analysis for HSD was 0.781, 0.804, 0.770, respectively. HSD < 9439.5 μm2 predicted high BP and arterial stiffness (95% CI in all participants: baPWV, 0.681–0.881, SBP, 0.709–0.900, DBP, 0.672–0.867, p < 0.001). These results suggest that OMA is a sensitive index to predict arterial stiffness in HTN population.
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影响因子：
3
作者：
Rakymzhan A;Li Y;Tang P;Wang RK
通讯作者：
Wang RK
影响因子：
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Chua J;Le TT;Tan B;Ke M;Li C;Wong DWK;Tan ACS;Lamoureux E;Wong TY;Chin CWL;Schmetterer L
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影响因子：
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通讯作者：
MacGregor, Graham A.
影响因子：
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作者：
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通讯作者：
Schlaich MP
影响因子：
4.6
作者：
Kwiatkowski G;Bar A;Jasztal A;Chłopicki S
通讯作者：
Chłopicki S