The role of dopamine signaling in epileptogenesis.
The role of dopamine signaling in epileptogenesis.
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DOI：
10.3389/fncel.2013.00157
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发表时间：
2013-09-17
影响因子：
5.3
通讯作者：
Borrelli E
中科院分区：
文献类型：
--
作者：
Bozzi Y;Borrelli E
临床和实验研究表明，大多数神经调节系统参与癫痫的发生。多巴胺能系统具有神经调节作用，其关键取决于所涉及的多巴胺（DA）受体的不同亚型和它们被激活的脑区域。具体而言，DA在控制边缘系统中出现的癫痫发作中起主要作用。在各种动物模型中进行的研究有助于说明边缘癫痫发生中D1样和D2样受体信号传导的相反作用。事实上，来自D1样受体的信号传导通常是促癫痫的，而D2样受体信号传导发挥抗癫痫作用。然而，这种观点可能显得相当简单，因为DA在控制癫痫发生中的复杂神经调节作用可能需要由这两种主要DA受体亚型调节的回路激活中的生理平衡，这决定了对癫痫促进刺激的反应。在这里，我们将审查最近的证据，在边缘系统癫痫发作的产生和传播中的DA转导通路激活的分子的识别。我们将讨论不同的DA受体激活触发的细胞内信号通路，其在边缘癫痫发生，导致激活神经元死亡/生存级联反应的作用。深入了解癫痫发生中的信号通路对于识别治疗癫痫的新靶点至关重要。
Clinical and experimental studies implicate most neuromodulatory systems in epileptogenesis. The dopaminergic system has a seizure-modulating effect that crucially depends on the different subtypes of dopamine (DA) receptors involved and the brain regions in which they are activated. Specifically, DA plays a major role in the control of seizures arising in the limbic system. Studies performed in a wide variety of animal models contributed to illustrate the opposite actions of D1-like and D2-like receptor signaling in limbic epileptogenesis. Indeed, signaling from D1-like receptors is generally pro-epileptogenic, whereas D2-like receptor signaling exerts an anti-epileptogenic effect. However, this view might appear quite simplistic as the complex neuromodulatory action of DA in the control of epileptogenesis likely requires a physiological balance in the activation of circuits modulated by these two major DA receptor subtypes, which determines the response to seizure-promoting stimuli. Here we will review recent evidences on the identification of molecules activated by DA transduction pathways in the generation and spread of seizures in the limbic system. We will discuss the intracellular signaling pathways triggered by activation of different DA receptors in relation to their role in limbic epileptogenesis, which lead to the activation of neuronal death/survival cascades. A deep understanding of the signaling pathways involved in epileptogenesis is crucial for the identification of novel targets for the treatment of epilepsy.
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影响因子：
3.3
作者：
BOUTHENET, ML;MARTRES, MP;SCHWARTZ, JC
通讯作者：
SCHWARTZ, JC
影响因子：
3.3
作者：
ALAM, AM;STARR, MS
通讯作者：
STARR, MS
影响因子：
9.9
作者：
Ciumas, C.;Wahlin, T. -B. Robins;Savic, I.
通讯作者：
Savic, I.
影响因子：
5.7
作者：
Ciumas, Carolina;Wahlin, Tarja-Brita Robins;Savic, Ivanka
通讯作者：
Savic, Ivanka
影响因子：
4.7
作者：
Chen, SC
通讯作者：
Chen, SC