Nutritional modulation of age-related macular degeneration.
Nutritional modulation of age-related macular degeneration.
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DOI：
10.1016/j.mam.2012.03.005
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发表时间：
2012-08
影响因子：
10.6
通讯作者：
Taylor, Allen
中科院分区：
文献类型：
--
作者：
Weikel, Karen A.;Chiu, Chung-Jung;Taylor, Allen
老年性黄斑变性(AMD)是全球老年人致盲的主要原因。它影响着3000-5000万人，在工业化国家中，至少有三分之一的75岁以上的人患有AMD的临床特征。与AMD相关的成本超过3400亿美元。美国的大多数AMD患者没有资格接受临床治疗。通过饮食调节进行预防干预是很有吸引力的策略，因为许多研究表明，微量和大量营养素对AMD以及其他与年龄相关的疾病有好处，而且几乎没有不良影响。保持视力将提高数百万老年人的生活质量，并减轻AMD的个人和公共卫生财政负担。观察研究表明，保持充足的omega-3脂肪酸水平(即每周2份鱼)或低血糖指数饮食可能对早期AMD特别有益，而较高水平的类胡萝卜素可能对新生血管性AMD具有保护作用。为了更好地了解这些营养素和/或营养素组合对视网膜健康的全部影响，需要进行干预试验。描述营养对AMD发病和/或进展的影响的分析是有价值的，因为它们表明了在早期阶段营养对阻止AMD的价值。这份全面的摘要提供了有关营养在降低AMD发病或进展风险方面的价值的基本信息，并可作为指南，直到正在进行的干预试验的数据可用。
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly worldwide. It affects 30–50 million individuals and clinical hallmarks of AMD are observed in at least one third of persons over the age of 75 in industrialized countries. Costs associated with AMD are in excess of $340 billion US. The majority of AMD patients in the United States are not eligible for clinical treatments. Preventive interventions through dietary modulation are attractive strategies because many studies suggest a benefit of micro and macronutrients with respect to AMD, as well as other age-related debilities, and with few, if any, adverse effects. Preservation of vision would enhance quality of life for millions of elderly people, and alleviate the personal and public health financial burden of AMD. Observational studies indicate that maintaining adequate levels of omega-3 fatty acids (i.e. with 2 servings/wk of fish) or a low glycemic index diet may be particularly beneficial for early AMD and that higher levels of carotenoids may be protective, most probably, against neovascular AMD. Intervention trials are needed to better understand the full effect of these nutrients and/or combinations of nutrients on retinal health. Analyses that describe effects of a nutrient on onset and/or progress of AMD are valuable because they indicate the value of a nutrient to arrest AMD at the early stages. This comprehensive summary provides essential information about the value of nutrients with regard to diminishing risk for onset or progress of AMD and can serve as a guide until data from ongoing intervention trials are available.
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影响因子：
7.1
作者：
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