Two-Dimensional Ti(3)C(2) MXene for High-Resolution Neural Interfaces.
Two-Dimensional Ti(3)C(2) MXene for High-Resolution Neural Interfaces.
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DOI：
10.1021/acsnano.8b06014
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发表时间：
2018-10-23
期刊：
影响因子：
17.1
通讯作者：
Vitale F
中科院分区：
文献类型：
--
作者：
Driscoll N;Richardson AG;Maleski K;Anasori B;Adewole O;Lelyukh P;Escobedo L;Cullen DK;Lucas TH;Gogotsi Y;Vitale F
高分辨率的神经接口是研究和调节大脑功能和疾病背后的神经回路的重要工具。由于电极小型化以实现更高的空间分辨率和通道数，因此保持低阻抗和高信号质量成为重大挑战。纳米结构材料可以解决这一挑战，因为它们结合了高导电性和机械柔韧性，并且可以在分子尺度上与生物系统相互作用。不幸的是，用纳米结构材料制造高分辨率神经接口通常既昂贵又耗时，而且无法规模化，这就阻碍了将其应用到台式设备之外。在碳基纳米材料中，二维Ti3C2 MXene具有非常高的体积电容、电导率、表面功能和可加工性。在这里，我们提出了一种构建Ti3C2神经电子器件的高通量微加工工艺，并与标准金属微电极相比，展示了其优越的阻抗和体内神经记录性能。具体来说，与相同尺寸的金微电极相比，Ti3C2电极的界面阻抗降低了4倍。此外，麻醉大鼠术中多个时空尺度的脑内记录表明，Ti3C2电极比金电极具有更低的基线噪声、更高的信噪比和更低的60 Hz干扰敏感性。最后，在神经元生物相容性研究中，在Ti3C2上培养的神经元与对照培养的神经元一样有活力，它们可以粘附，生长轴突，形成功能网络。总之，我们的研究结果表明，Ti3C2 MXene微电极有潜力成为高分辨率生物界面的强大平台技术。
High-resolution neural interfaces are essential tools for studying and modulating neural circuits underlying brain function and disease. Because electrodes are miniaturized to achieve higher spatial resolution and channel count, maintaining low impedance and high signal quality becomes a significant challenge. Nanostructured materials can address this challenge because they combine high electrical conductivity with mechanical flexibility and can interact with biological systems on a molecular scale. Unfortunately, fabricating high-resolution neural interfaces from nanostructured materials is typically expensive and time-consuming and does not scale, which precludes translation beyond the benchtop. Two-dimensional (2D) Ti3C2 MXene possesses a combination of remarkably high volumetric capacitance, electrical conductivity, surface functionality, and processability in aqueous dispersions distinct among carbon-based nanomaterials. Here, we present a high-throughput microfabrication process for constructing Ti3C2 neuroelectronic devices and demonstrate their superior impedance and in vivo neural recording performance in comparison with standard metal microelectrodes. Specifically, when compared to gold microelectrodes of the same size, Ti3C2 electrodes exhibit a 4-fold reduction in interface impedance. Furthermore, intraoperative in vivo recordings from the brains of anesthetized rats at multiple spatial and temporal scales demonstrate that Ti3C2 electrodes exhibit lower baseline noise, higher signal-to-noise ratio, and reduced susceptibility to 60 Hz interference than gold electrodes. Finally, in neuronal biocompatibility studies, neurons cultured on Ti3C2 are as viable as those in control cultures, and they can adhere, grow axonal processes, and form functional networks. Overall, our results indicate that Ti3C2 MXene microelectrodes have the potential to become a powerful platform technology for high-resolution biological interfaces.
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影响因子：
56.7
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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影响因子：
8.6
作者：
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通讯作者：
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