MR susceptibility imaging.

MR susceptibility imaging.
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DOI:
10.1016/j.jmr.2012.11.013
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发表时间:
2013-04
影响因子:
2.2
通讯作者:
Duyn, Jeff
Duyn, Jeff
中科院分区:
化学3区
文献类型:
--
作者:
Duyn, Jeff

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这项工作回顾了最近的发展,在使用磁化率对比人类MRI,重点是大脑解剖学的研究。现代高场扫描仪的敏感性对比度的增加导致了对脑组织中这种对比度的来源和机制的新应用和见解。专门的实验已经证明,在大多数健康的大脑中,铁和髓磷脂主导组织易感性变化,尽管它们的相对贡献差异很大。这些化合物的局部变化会影响MRI信号的振幅和频率。在白色物质中,髓鞘引入了各向异性的磁化率,其对轴突内、髓鞘和轴突空间之间的水隔室具有不同的影响,并且使它们的信号依赖于轴突和磁场之间的角度。这提供了获得这些细胞区室特有的组织特性的机会。
This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy. The increase in susceptibility contrast with modern high field scanners has led to novel applications and insights into the sources and mechanism contributing to this contrast in brain tissues. Dedicated experiments have demonstrated that in most of healthy brain, iron and myelin dominate tissue susceptibility variations, although their relative contribution varies substantially. Local variations in these compounds can affect both amplitude and frequency of the MRI signal. In white matter, the myelin sheath introduces an anisotropic susceptibility that has distinct effects on the water compartments inside the axons, between the myelin sheath, and the axonal space, and renders their signals dependent on the angle between the axon and the magnetic field. This offers opportunities to derive tissue properties specific to these cellular compartments.
DOI: 10.1097/wco.0b013e328348972a
发表时间: 2011-08
影响因子: 4.8
作者:
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通讯作者: Koretsky AP
DOI: 10.1002/mrm.1910130207
发表时间: 1990-02-01
影响因子: 3.3
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发表时间: 2012-08-15
期刊: NEUROIMAGE
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