Membrane Contact Sites and Organelles Interaction in Plant Autophagy
Membrane Contact Sites and Organelles Interaction in Plant Autophagy
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植物自噬中的膜接触位点和细胞器相互作用
DOI：
10.3389/fpls.2020.00477
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发表时间：
2020-04
影响因子：
5.6
通讯作者：
Liwen Jiang
中科院分区：
文献类型：
--
作者：
Hao Ye;Changyang Ji;Rongfang Guo;Liwen Jiang
自噬是一种细胞内运输和降解系统，用于回收受损的细胞器、错误折叠的蛋白质和细胞质成分。根据货物规格，自噬可分为非选择性自噬和选择性自噬。该过程的关键是自噬体的及时形成，自噬体是一种双膜结构，负责将受损的细胞器和蛋白质递送至溶酶体或液泡进行周转。自噬体是由杯形吞噬泡的闭合形成的，这取决于与膜贡献者的正确通讯。内质网 (ER) 是自噬体生物发生的主要膜来源，ER 通过膜接触位点 (MCS) 与吞噬细胞连接。 MCS 是细胞器膜之间紧密排列的区域，脂质和信号在此交换。脂质转移蛋白 (LTP) 是一个大的蛋白质家族，包括氧甾醇结合蛋白相关蛋白 (ORP)，它可以在 MCS 中找到并介导哺乳动物和酵母中的脂质转移。此外，选择性自噬还可以检测自噬体与其他细胞器之间的相互作用，以选择和降解各种受损的细胞器。选择性自噬是通过货物和自噬体之间的受体或接头的结合介导的。在这里，我们总结了我们对真核生物自噬体和其他细胞器之间 MCS 的了解。然后，我们讨论了对植物 MCS 中 ORP 的理解进展以及植物选择性自噬的潜在机制，重点是参与自噬体与其他细胞质成分相互作用的受体/适配器，包括 BRCA1 基因的邻居 1 (NBR1)、ATG8 相互作用蛋白 1 (ATI1)、调节颗粒非 ATP 酶 10 (RPN10) 和显性颗粒KAR2 (DSK2) 的抑制剂。
Autophagy is an intracellular trafficking and degradation system for recycling of damaged organelles, mis-folded proteins and cytoplasmic constituents. Autophagy can be divided into non-selective autophagy and selective autophagy according to the cargo specification. Key to the process is the timely formation of the autophagosome, a double-membrane structure which is responsible for the delivery of damaged organelles and proteins to lysosomes or vacuoles for their turnover. Autophagosomes are formed by the closure of cup-shaped phagophore which depends on the proper communication with membrane contributors. The endoplasmic reticulum (ER) is a major membrane source for autophagosome biogenesis whereby the ER connects with phagophore through membrane contact sites (MCSs). MCSs are closely apposed domains between organelle membranes where lipids and signals are exchanged. Lipid transfer proteins (LTPs) are a large family of proteins including Oxysterol-binding protein related proteins (ORP) which can be found at MCSs and mediate lipid transfer in mammals and yeast. In addition, interaction between autophagosomes and other organelles can also be detected in selective autophagy for selection and degradation of various damaged organelles. Selective autophagy is mediated by the binding of a receptor or an adaptor between a cargo and an autophagosome. Here we summarize what we know about the MCS between autophagosomes and other organelles in eukaryotes. We then discuss progress in our understanding about ORPs at MCSs in plants and the underlying mechanisms of selective autophagy in plants with a focus on receptors/adaptors that are involved in the interaction of the autophagosome with other cytoplasmic constituents, including the Neighbor of BRCA1 gene 1 (NBR1), ATG8-interacting protein 1 (ATI1), Regulatory Particle Non-ATPase 10 (RPN10), and Dominant Suppressor of KAR2 (DSK2).
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DOI：
10.1126/science.aan5835
发表时间：
2018-08-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Wu H;Carvalho P;Voeltz GK
通讯作者：
Voeltz GK
影响因子：
5.6
作者：
Izumi M;Nakamura S
通讯作者：
Nakamura S
影响因子：
6.9
作者：
Siao W;Wang P;Voigt B;Hussey PJ;Baluska F
通讯作者：
Baluska F
影响因子：
5.3
作者：
Obara K;Ohsumi Y
通讯作者：
Ohsumi Y
影响因子：
16.6
作者：
Wijdeven RH;Janssen H;Nahidiazar L;Janssen L;Jalink K;Berlin I;Neefjes J
通讯作者：
Neefjes J