DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities.
DLBS1033, a protein extract from Lumbricus rubellus, possesses antithrombotic and thrombolytic activities.
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DLBS1033是lumbricus rubellus的蛋白质提取物，具有抗血栓形成和溶栓活性。
DOI：
10.1155/2011/519652
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发表时间：
2011
影响因子：
--
通讯作者：
Tjandrawinata RR
中科院分区：
文献类型：
--
作者：
Trisina J;Sunardi F;Suhartono MT;Tjandrawinata RR
早在亚洲古代医学史上，甘草的药用价值就已广为人知。本研究的目的是确定一个标准化的提取物红地龙命名为DLBS 1033的作用和效果的机制。采用人血进行纤维蛋白原降解、抗血小板聚集和离体抗血栓试验，以研究抗血栓活性。用平板法和血栓溶解法检测其溶栓性能。发现DLBS 1033对纤维蛋白原的α-、β-和γ-链具有纤维蛋白原溶解活性。它还诱导抗血小板聚集和延长血液凝固时间，这进一步证实了它的抗血栓形成特性。此外，DLBS 1033的血栓溶解特性显示出其快速和长效的纤溶活性，以及其有效的血块溶解活性。结论：DLBS 1033具有抗血栓和溶栓作用，可作为一种安全、有前途的口服溶栓药物。
The medicinal value of earthworm has been widely known since the history of Asian ancient medicine. This present study aims to determine the mechanism of action and effect of a standardized extract of Lumbricus rubellus named as DLBS1033. The fibrinogen degradation, antiplatelet aggregation, and ex vivo antithrombotic assay using human blood were performed to study antithrombotic activity. Fibrin plate and clot lysis assay were also done to examine thrombolytic properties. DLBS1033 was found to possess fibrinogenolytic activity on α-, β-, and γ-chain of fibrinogen. It also induced antiplatelet aggregation and prolonged blood clotting time, which further confirmed its antithrombotic properties. In addition, thrombolytic properties of DLBS1033 were shown with its fast and long-acting fibrinolytic activity, as well as its effective blood clot lysis activities. In conclusion, DLBS1033 conferred antithrombotic and thrombolytic action which could be used as a safe and promising oral thrombolytic drug.
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影响因子：
37.8
作者：
Freedman, JE
通讯作者：
Freedman, JE
影响因子：
3.1
作者：
Prasad S;Kashyap RS;Deopujari JY;Purohit HJ;Taori GM;Daginawala HF
通讯作者：
Daginawala HF
影响因子：
--
作者：
Zhao J;Pan R;He J;Liu Y;Li DF;He RQ
通讯作者：
He RQ
影响因子：
7.5
作者：
MATSUDA, T;MURAKAMI, M
通讯作者：
MURAKAMI, M
影响因子：
2
作者：
Yan, Xiang Mei;Kim, Chung-Hyo;Sohn, Uy Dong
通讯作者：
Sohn, Uy Dong