Synthesis and photodynamic effect of new highly photostable decacationically armed [60]- and [70]fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells.
Synthesis and photodynamic effect of new highly photostable decacationically armed [60]- and [70]fullerene decaiodide monoadducts to target pathogenic bacteria and cancer cells.
复制标题
DOI：
10.1021/jm3000664
复制
发表时间：
2012-05-10
影响因子：
7.3
通讯作者：
Chiang, Long Y.
中科院分区：
文献类型：
--
作者：
Wang, Min;Huang, Liyi;Sharma, Sulbha K.;Jeon, Seaho;Thota, Sammaiah;Sperandio, Felipe F.;Nayka, Suhasini;Chang, Julie;Hamblin, Michael R.;Chiang, Long Y.
合成了新型水溶性十阳离子臂C60和C70十碘烷单加合物C60-或C70[>M（C3 N6 +C3）2]，表征了其结构，并将其作为光敏剂和潜在的纳米PDT剂应用于病原菌和癌细胞。大量的阳离子电荷，每个富勒烯笼和H-键合部分被设计用于快速结合到细菌细胞壁的外部上显示的阴离子残基。在臂区存在大量的给电子碘阴离子作为季铵盐的一部分时，我们发现C70[>M（C3 N6 +C3）2]比C60[>M（C3 N6 + C3）2]除了产生1 O2外，还产生更多的HO·。这一发现提供了C60[>M（C3 N6 +C3）2]和C70[>M（C3 N6 + C3）2]分别优先杀死革兰氏阳性和革兰氏阴性细菌的解释。假设1 O2可以更容易地扩散到革兰氏阳性细菌的多孔细胞壁中以到达敏感部位，而渗透性较低的革兰氏阴性细菌细胞壁需要更具反应性的HO·来引起真实的损伤。
Novel water-soluble decacationically armed C60 and C70 decaiodide monoadduct, C60- or C70[>M(C3N6+C3)2] were synthesized, characterized, and applied as photosensitizers and potential nano-PDT agents against pathogenic bacteria and cancer cells. A high number of cationic charges per fullerene cage and H-bonding moieties were designed for rapid binding to the anionic residues displayed on the outer parts of bacterial cell walls. In the presence of a high number of electron-donating iodide anions as parts of quaternary ammonium salts in the arm region, we found that C70[>M(C3N6+C3)2] produced more HO• than C60[>M(C3N6+C3)2], in addition to 1O2. This finding offers an explanation of the preferential killing of Gram-positive and Gram-negative bacteria by C60[>M(C3N6+C3)2] and C70[>M(C3N6+C3)2], respectively. The hypothesis is that 1O2 can diffuse more easily into porous cell walls of Gram-positive bacteria to reach sensitive sites, while the less permeable Gram-negative bacterial cell wall needs the more reactive HO• to cause real damage.
登录
查看更多内容
影响因子：
4.8
作者：
Setsukinai, K;Urano, Y;Nagano, T
通讯作者：
Nagano, T
影响因子：
17.1
作者：
Kell, Arnold J.;Stewart, Gale;Simard, Benoit
通讯作者：
Simard, Benoit
影响因子：
3.2
作者：
DAHL, TA;MIDDEN, WR;HARTMAN, PE
通讯作者：
HARTMAN, PE
影响因子：
2.7
作者：
Jett, BD;Hatter, KL;Gilmore, MS
通讯作者：
Gilmore, MS
影响因子：
3.1
作者：
Mroz, Pawel;Tegos, George P.;Hamblin, Michael R.
通讯作者：
Hamblin, Michael R.