Failure of the hypothalamic noradrenergic system to function in adult androgen-sterilized rats.
Failure of the hypothalamic noradrenergic system to function in adult androgen-sterilized rats.
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成年雄激素绝育大鼠下丘脑去甲肾上腺素能系统无法发挥作用。
DOI：
10.1095/biolreprod27.2.268
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发表时间：
1982
影响因子：
3.6
通讯作者：
Barraclough,CA
中科院分区：
文献类型：
--
作者：
Lookingland,KJ;Wise,PM;Barraclough,CA
我们测定了去卵巢(OVX)、雌激素处理的成年对照大鼠和雄性不育大鼠(5日龄50μg丙酸睾丸酮)下丘脑微区去甲肾上腺素(NE)和多巴胺(DA)的初始浓度、速率常数和周转率，以及促性腺激素释放。对照组大鼠去卵巢后1周(第0天)植入含雌二醇(E_2)的硅胶胶囊，黄体生成素(L H)在第3天和第4天出现下午高峰。在第3天的0900h，雌激素性卵巢切除的对照组，下午的黄体生成素血浆峰浓度显著增加。相反，相同的E2或E2P处理的成年去卵巢ASR患者在放置E2胶囊后的第3天或第4天对血浆黄体生成素没有影响。记录正常大鼠与ASR大鼠血清卵泡刺激素(FSH)、催乳素(PRL)、雌二醇(E_2)、孕酮(P)的浓度差异及雌二醇对这些激素水平的影响。在接受雌激素治疗的ASR患者中，在所有被检查的脑区中，NE的初始稳态浓度显著低于对照组。对照组正中隆起(ME)、视前内侧核(MPN)、视交叉上核(SCN)的NE周转率在1500~1700h较1000~1200h显著增加，但弓状核(AN)的NE周转率无明显变化。下午，MPN和ME的NE周转率没有增加，而SCN和E_2处理的ASR的周转率仅略有增加。对照组和ASR组的DA周转率在上午和下午之间呈下降趋势。在对照组大鼠，AN和MPN的DA周转率在下午增加，但在ASR的相同下丘脑区保持不变。大量研究表明，NE可能是正常发情大鼠或去卵巢大鼠ME轴突终末释放黄体激素释放激素(LHRH)的神经触发物质。NE不能被释放到ASR的MPN和ME中可能是雌二醇不能在这些动物中引起黄体生成素高峰的原因。
We have examined norepinephrine (NE) and dopamine (DA) initial concentrations, rate constants and turnover rates in microdissected regions of the hypothalamus and gonadotropin release in ovariectomized (OVX)estrogen-treated adult control and androgen-sterilized rats (ASR) (50μg testosterone propionate at 5 days of age). When Silastic capsules containing estradiol (E2) were implanted one week after ovariectomy (Day 0) in control rats, afternoon luteinizing hormone (LH) surges occurred on Days 3 and 4. When 2 progesterone (P) silastic capsules were placed s.c. on Day 3 at 0900 h into E2-primed ovariectomized controls, the afternoon LH plasma surge concentrations were markedly amplified. In contrast, identical E2or E2P treatment of adult ovariectomized ASR had no effect on plasma LH on either Days 3 or 4 after E2capsule placement. Serum concentration differences of follicle-stimulating hormone (FSH), prolactin (Prl), E2and P between control rats and ASR and the effects of E2treatment on these hormone levels also were recorded. In E2-treated ASR, initial steady state concentrations of NE were significantly less than in controls in all brain regions examined. NE turnover rates increased significantly in E2-treated controls at 1500–1700 h compared to those at 1000–1200 h in median eminence (ME), medial preoptic nucleus (MPN), suprachiasmatic nucleus (SCN) but not in arcuate nucleus (AN). No increase in NE turnover rates occurred in MPN and ME and only slight increases in turnovers were observed in SCN and AN in E2-treated ASR during the afternoon. DA turnover rates declined between morning and afternoon in ME of control and ASR. In control rats, DA turnover rates increased during the afternoon in AN and MPN but remained unchanged in these same hypothalamic regions in ASR. A considerable amount of previous evidence suggests that NE may be the neural trigger which evokes the release of luteinizing hormone releasing hormone (LHRH) from ME axon terminals in normal proestrous or in E2-treated ovariectomized rats. The failure of NE to be released into the MPN and ME of ASR may account for the failure of estradiol to induce LH surges in these animals.
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进一步的证据表明黄体生成素释放激素也是卵泡刺激素释放激素。
影响因子：
4.8
作者：
P. M. Wise;Naomi Rance;George D. Barr;C. Barraclough
通讯作者：
C. Barraclough
雌激素对雄性和雌性大鼠下丘脑中孕激素受体的诱导，其表现出周期性促性腺激素分泌和雌性性行为的能力不同。
影响因子：
3.6
作者：
A. M. Etgen
通讯作者：
A. M. Etgen
恒定光和雄激素灭菌对结节漏斗多巴胺神经元胺周转的影响：阻断循环活动并诱导正中隆起持续高多巴胺周转。
DOI：
10.1530/acta.0.0690625
发表时间：
1972
期刊：
Acta endocrinologica
影响因子：
--
作者：
K. Fuxe;T. Hökfelt;O. Nilsson
通讯作者：
O. Nilsson
第 19 章 – 产前和产后早期接触激素后生殖功能的改变
DOI：
10.1016/b978-1-4832-3229-4.50010-5
发表时间：
1967
影响因子：
--
作者：
C. Barraclough
通讯作者：
C. Barraclough
影响因子：
4.8
作者：
BARRACLOUGH, C
通讯作者：
BARRACLOUGH, C