The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water.
The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water.
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DOI：
10.1016/j.reprotox.2008.11.001
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发表时间：
2009-06
影响因子：
3.3
通讯作者：
Emmett, Edward A.
中科院分区：
文献类型：
--
作者：
Nolan, Lynda A.;Nolan, John M.;Shofer, Frances S.;Rodway, Nancy V.;Emmett, Edward A.
关键词：
最近的研究已经检验了脐带血和母体血浆中的全氟辛酸(PFOA)水平与人类出生体重和胎龄降低之间的关系；然而，还没有研究在已知高PFOA暴露的人群中检验这些影响。俄亥俄州华盛顿县的小霍金水协(LHWA)的居民饮用全氟辛烷磺酸污染的水时，血清中的全氟辛烷磺酸水平大约是美国普通人口的80倍。将居住在邮政编码的母亲所生新生儿的出生体重和孕周与LHWA完全、部分或根本不提供水服务的新生儿进行比较。对俄亥俄州卫生部提供的单胎新生儿出生体重数据进行了多元Logistic和线性回归分析，以检验LHWA供水服务类别(用作全氟辛烷磺酸暴露的替代物)与平均出生体重、平均孕龄、低出生体重(<；2500克)和早产(<；37周妊娠)的可能性之间的关系。所有的模型都根据母亲的年龄、胎龄、性别、种族和人口水平的社会经济地位进行了调整。低出生体重、早产、新生儿平均出生体重和平均胎龄的发生率在不同供水服务类别之间没有显著差异。全氟辛烷磺酸暴露显著增加，按供水服务类别分类，与出生体重或胎龄降低的风险增加无关。这项研究没有证实早先发现的全氟辛酸与正常人口水平下观察到的低出生体重之间的关联。
Recent studies have examined the associations between perfluorooctanoic acid (PFOA) levels in cord blood and maternal plasma with lowered birth weight and gestational age in humans; however, no study has examined these effects in a population of known high PFOA exposure. Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population. To compare birth weights and gestational ages of neonates born to mothers residing in zip codes with water service provided completely, partially or not at all by the LHWA. Multiple logistic and linear regression analyses were performed on singleton neonatal birth weight data supplied by the Ohio Department of Health to examine the associations between LHWA water service category (used as a surrogate for PFOA exposure) with mean birth weight, mean gestational age, the likelihood of low birth weight (<2500 grams), and the likelihood of preterm birth (<37 completed weeks of gestation). All models were adjusted for maternal age, gestational age, sex, race and population-level socioeconomic status. The incidence of low birth weight, preterm birth, mean birth weight and mean gestational age of neonates did not significantly differ among water service categories. Markedly elevated PFOA exposure, as categorized by water service category, is not associated with increased risk of lowered birth weight or gestational age. This study does not confirm earlier findings of an association between PFOA and lowered birth weight observed at normal population levels.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5.8
作者：
Hofman, PL;Cutfield, WS;Gluckman, PD
通讯作者：
Gluckman, PD
DOI：
10.1097/01.jom.0000233380.13087.37
发表时间：
2006-08-01
影响因子：
3.2
作者：
Emmett, Edward Anthony;Zhang, Hong;Shaw, Leslie Michael
通讯作者：
Shaw, Leslie Michael
影响因子：
5
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
11.4
作者：
Kannan, K;Koistinen, J;Giesy, JP
通讯作者：
Giesy, JP