Interactions between Innate Immunity, Microbiota, and Probiotics.
Interactions between Innate Immunity, Microbiota, and Probiotics.
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DOI：
10.1155/2015/501361
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发表时间：
2015
影响因子：
4.1
通讯作者：
Tursi A
中科院分区：
文献类型：
--
作者：
Giorgetti G;Brandimarte G;Fabiocchi F;Ricci S;Flamini P;Sandri G;Trotta MC;Elisei W;Penna A;Lecca PG;Picchio M;Tursi A
“微生物群”一词是指与微生物群相关的基因遗传，微生物群比客人大100倍左右。常驻细菌植物群的耐受性是免疫细胞功能的重要关键因素。在宿主与微生物群之间的相互作用中，潘氏细胞发挥关键作用，其能够合成和分泌蛋白质和抗微生物肽，如α/β防御素、cathelicidin、14 β-糖苷酶、C型凝集素和核糖核酸酶，以响应各种刺激。最近的研究发现益生菌能够通过下调免疫反应和诱导T调节细胞的发育来保持肠道内稳态。特定的益生菌菌株，以及益生菌驱动的代谢产物称为“postbiotics”，最近已被认识到，它能够影响先天免疫。基于益生菌的新治疗方法现已推出，未来还将推出基于益生菌的进一步治疗方法。
The term “microbiota” means genetic inheritance associated with microbiota, which is about 100 times larger than the guest. The tolerance of the resident bacterial flora is an important key element of immune cell function. A key role in the interaction between the host and the microbiota is played by Paneth cell, which is able to synthesize and secrete proteins and antimicrobial peptides, such as α/β defensins, cathelicidin, 14 β-glycosidases, C-type lectins, and ribonuclease, in response to various stimuli. Recent studies found probiotics able to preserve intestinal homeostasis by downmodulating the immune response and inducing the development of T regulatory cells. Specific probiotic strain, as well as probiotic-driven metabolic products called “postbiotics,” has been recently recognized and it is able to influence innate immunity. New therapeutic approaches based on probiotics are now available, and further treatments based on postbiotics will come in the future.
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影响因子：
8
作者：
Moendel, M.;Schroeder, B. O.;Zimmermann, K.;Huber, H.;Nuding, S.;Beisner, J.;Fellermann, K.;Stange, E. F.;Wehkamp, J.
通讯作者：
Wehkamp, J.
DOI：
10.1073/pnas.0910307107
发表时间：
2010-01-05
影响因子：
11.1
作者：
Pagnini, Cristiano;Saeed, Rubina;Cominelli, Fabio
通讯作者：
Cominelli, Fabio
影响因子：
3.6
作者：
Dykstra, Natalie S.;Hyde, Lucie;Mack, David R.
通讯作者：
Mack, David R.
影响因子：
2.3
作者：
Cucchiara, Salvatore;Iebba, Valerio;Schippa, Serena
通讯作者：
Schippa, Serena
影响因子：
10.8
作者：
Ha, Tuanzhu;Hu, Yulong;Li, Chuanfu
通讯作者：
Li, Chuanfu