A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy.
A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy.
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DOI：
10.1371/journal.pntd.0000870
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发表时间：
2010-11-02
影响因子：
3.8
通讯作者：
Stoner JA
中科院分区：
文献类型：
--
作者：
Ndimubanzi PC;Carabin H;Budke CM;Nguyen H;Qian YJ;Rainwater E;Dickey M;Reynolds S;Stoner JA
本研究的目的是对全球范围内报道神经囊虫病（NCC）发病率的研究进行系统回顾。系统检索PubMed、英联邦农业局（CAB）摘要和23个国际数据库，检索1990年1月1日至2008年6月1日发表的文章。至少有两名研究人员对文章的纳入进行评估，重点关注研究设计和方法。使用标准化表格独立提取数据。采用随机效应二项模型估计癫痫（PWE）患者NCC的比例。总共检索到565篇文章，其中290篇（51%）被选中进行进一步分析。在第二个分析阶段之后，只有4.5%的文章（所有使用神经影像学诊断NCC的文章）被回顾。只有两项研究（均来自美国）使用出院数据估算了NCC的发病率。一项研究报告了随机抽样的村庄居民中NCC的患病率，其中9.1%的人口患有NCC脑病变。不同研究人群中NCC的比例差异很大。然而，NCC在PWE中的比例更为一致。该人群的合并估计为29.0% （95%CI: 22.9%-35.5%）。这些结果对纳入或排除任何特定研究并不敏感。只有一项研究在所有居民的随机样本中估计了NCC的患病率。因此，全球范围内NCC的患病率仍然未知。然而，对PWE中NCC比例的汇总估计非常可靠，可以与癫痫患病率和发病率的估计一起使用，以估计流行地区NCC负担的这一部分。以前建议的诊断过程指南和宣布非传染性细胞癌为国际应报告疾病的指南将提高对非传染性细胞癌全球发病率的认识。神经囊虫病（NCC）是一种由猪带绦虫引起的脑部寄生虫感染，可感染人类和猪。关于这种疾病的病例报告和流行病学研究越来越多，但其全球发病率从未确定，部分原因是血液检查对非细胞癌的诊断不是很好。在此，我们对全球范围内神经影像学诊断NCC的文献进行了系统回顾。总的来说，565篇文章被检索到，290篇（51%）被选择进一步审查。其中，只有26个有足够有效的信息来估计NCC在不同人群中的频率。只有一项研究估计了NCC在普通人群中的患病率。最引人注目的发现是，在拉丁美洲、撒哈拉以南非洲和东南亚进行的12项研究中，癫痫患者中NCC的比例非常一致，估计为29.6%（95%置信区间：23.5%-36.1%）。加强建议的诊断过程通用指南，宣布非传染性细胞癌为国际可报告疾病，并使数据收集程序标准化，可以提高我们对全球非传染性细胞癌发病率及其全球负担的了解。
The objective of this study is to conduct a systematic review of studies reporting the frequency of neurocysticercosis (NCC) worldwide. PubMed, Commonwealth Agricultural Bureau (CAB) abstracts and 23 international databases were systematically searched for articles published from January 1, 1990 to June 1, 2008. Articles were evaluated for inclusion by at least two researchers focusing on study design and methods. Data were extracted independently using standardized forms. A random-effects binomial model was used to estimate the proportion of NCC among people with epilepsy (PWE). Overall, 565 articles were retrieved and 290 (51%) selected for further analysis. After a second analytic phase, only 4.5% of articles, all of which used neuroimaging for the diagnosis of NCC, were reviewed. Only two studies, both from the US, estimated an incidence rate of NCC using hospital discharge data. The prevalence of NCC in a random sample of village residents was reported from one study where 9.1% of the population harboured brain lesions of NCC. The proportion of NCC among different study populations varied widely. However, the proportion of NCC in PWE was a lot more consistent. The pooled estimate for this population was 29.0% (95%CI: 22.9%–35.5%). These results were not sensitive to the inclusion or exclusion of any particular study. Only one study has estimated the prevalence of NCC in a random sample of all residents. Hence, the prevalence of NCC worldwide remains unknown. However, the pooled estimate for the proportion of NCC among PWE was very robust and could be used, in conjunction with estimates of the prevalence and incidence of epilepsy, to estimate this component of the burden of NCC in endemic areas. The previously recommended guidelines for the diagnostic process and for declaring NCC an international reportable disease would improve the knowledge on the global frequency of NCC. Neurocysticercosis (NCC) is a parasitic infection of the brain caused by the tapeworm Taenia solium, which infects humans and pigs. There have been increasing case reports and epidemiological studies on this disease, but its global frequency has never been determined, partly due to the fact that blood tests are not very good for the diagnosis of NCC. We present here a systematic review of the literature on the frequency of NCC diagnosed with neuroimaging worldwide. Overall, 565 articles were retrieved and 290 (51%) selected for further review. Of those, only 26 had information valid enough to estimate the frequency of NCC in various populations. Only one study estimated the prevalence of NCC in the general population. The most striking finding was that the proportion of NCC among persons with epilepsy was very consistent and estimated at 29.6% (95%CI: 23.5%–36.1%) from 12 studies conducted in Latin America, Sub-Saharan Africa and Southeast Asia. A reinforcement of the suggested universal guidelines for the diagnostic process, declaring NCC an international reportable disease and standardizing procedures for data collection could improve our understanding of the frequency of NCC worldwide and hence its global burden.
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影响因子：
7.7
作者：
Herrera, LA;Benita-Bordes, A;Ostrosky-Wegman, P
通讯作者：
Ostrosky-Wegman, P
影响因子：
1.7
作者：
Hotez, Peter J.;Brown, Ami Shah
通讯作者：
Brown, Ami Shah
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
5.6
作者：
Del Brutto, OH;Santibáñez, R;García, HH
通讯作者：
García, HH
影响因子：
3
作者：
CARPIO, A;PLACENCIA, M;ESCOBAR, A
通讯作者：
ESCOBAR, A