Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T.
Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T.
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DOI：
10.1002/nbm.3613
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发表时间：
2016-11
影响因子：
2.9
通讯作者：
Bogner, Wolfgang
中科院分区：
文献类型：
--
作者：
Hnilicova, Petra;Povazan, Michal;Strasser, Bernhard;Andronesi, Ovidiu C.;Gajdosik, Martin;Dydak, Ulrike;Ukropec, Jozef;Dobrota, Dusan;Trattnig, Siegfried;Bogner, Wolfgang
关键词：
用磁共振成像（MRSI）获得的γ -氨基丁酸（GABA）定量结果的可重复性在健康成人的3t MR扫描仪上确定。在这项研究中，螺旋编码、GABA编辑、MEGA - LASER MRSI序列与实时运动扫描仪不稳定性校正被应用于大脑神经递质的鲁棒3D映射。特别测量了GABA+（即GABA加大分子污染）和Glx（即谷氨酸加谷氨酰胺污染）信号。该序列可在约20分钟内实现约3 cm3标称分辨率的3D - MRSI。由于GABA的可靠量化具有挑战性，因此通过对14名健康志愿者（7男7女）的重测评估，研究了GABA+和Glx水平在受试者间和受试者内部的空间分布变异性。对于受试者间和受试者内重复测量，在所有评估体素中，GABA+和Glx比率的变异系数（CV）较低，类内相关系数（ICC）较高（受试者内/受试者间：GABA+比率，CV ~ 8%-ICC > 0.75； Glx比率，CV ~ 6%-ICC > 0.70）。在选定的大脑区域中，Glx比率与GABA+比率也有相同的发现（CV从枕部和顶叶的约5%对约8%，到额部、丘脑和基底神经节的约8%对约10%）。这些结果提供了证据，证明使用所述方法对GABA+和Glx进行3D定位具有很高的可重复性，可用于临床和神经科学研究。
The reproducibility of gamma‐aminobutyric acid (GABA) quantification results, obtained with MRSI, was determined on a 3 T MR scanner in healthy adults. In this study, a spiral‐encoded, GABA‐edited, MEGA‐LASER MRSI sequence with real‐time motion–scanner‐instability corrections was applied for robust 3D mapping of neurotransmitters in the brain. In particular, the GABA+ (i.e. GABA plus macromolecule contamination) and Glx (i.e. glutamate plus glutamine contamination) signal was measured. This sequence enables 3D‐MRSI with about 3 cm3 nominal resolution in about 20 min. Since reliable quantification of GABA is challenging, the spatial distribution of the inter‐subject and intra‐subject variability of GABA+ and Glx levels was studied via test–retest assessment in 14 healthy volunteers (seven men–seven women). For both inter‐subject and intra‐subject repeated measurement sessions a low coefficient of variation (CV) and a high intraclass correlation coefficient (ICC) were found for GABA+ and Glx ratios across all evaluated voxels (intra−/inter‐subject: GABA+ ratios, CV ~ 8%–ICC > 0.75; Glx ratios, CV ~ 6%–ICC > 0.70). The same was found in selected brain regions for Glx ratios versus GABA+ ratios (CV varied from about 5% versus about 8% in occipital and parietal regions, to about 8% versus about 10% in the frontal area, thalamus, and basal ganglia). These results provide evidence that 3D mapping of GABA+ and Glx using the described methodology provides high reproducibility for application in clinical and neuroscientific studies.
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