Mucor circinelloides: a model organism for oleaginous fungi and its potential applications in bioactive lipid production.
Mucor circinelloides: a model organism for oleaginous fungi and its potential applications in bioactive lipid production.
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DOI：
10.1186/s12934-022-01758-9
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发表时间：
2022-02-28
影响因子：
6.4
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Fazili ABA;Shah AM;Zan X;Naz T;Nosheen S;Nazir Y;Ullah S;Zhang H;Song Y
微生物油因其在工业应用中的重要作用而受到广泛关注。目前，植物和动物是医学和营养上重要的脂肪酸的主要来源。然而，全球对多不饱和脂肪酸（PUFAs）不断增长的需求，现有的来源无法满足。因此，微生物，特别是真菌，是正在研究的微生物油的重要替代来源。环状毛霉（Mucor circinelloides）是一种产油丝状真菌，因其合成和积累γ-亚麻酸（GLA）等脂质效率高而备受关注。近年来，圆形m.s circinelloides的菌丝体被认为是通过脂质转化生产生物柴油的一种方便的原料来源，因此受到了极大的关注。尽管圆乳霉自然积累脂质，但代谢工程对其产量的大幅增加是重要的。对现有途径的修改和对圆叶霉生物合成途径的重组都显示出改善脂质水平的潜力。本文综述了近年来在环孢霉各重要代谢方面的研究进展。展望了其在抗氧化剂、营养药品、生物修复、乙醇生产以及β -胡萝卜素、虾青素等具有重要营养价值的类胡萝卜素等领域的潜在应用前景。在线版本包含补充材料，可在10.1186/s12934-022-01758-9获得。
Microbial oils have gained massive attention because of their significant role in industrial applications. Currently plants and animals are the chief sources of medically and nutritionally important fatty acids. However, the ever-increasing global demand for polyunsaturated fatty acids (PUFAs) cannot be met by the existing sources. Therefore microbes, especially fungi, represent an important alternative source of microbial oils being investigated. Mucor circinelloides—an oleaginous filamentous fungus, came to the forefront because of its high efficiency in synthesizing and accumulating lipids, like γ-linolenic acid (GLA) in high quantity. Recently, mycelium of M. circinelloides has acquired substantial attraction towards it as it has been suggested as a convenient raw material source for the generation of biodiesel via lipid transformation. Although M. circinelloides accumulates lipids naturally, metabolic engineering is found to be important for substantial increase in their yields. Both modifications of existing pathways and re-formation of biosynthetic pathways in M. circinelloides have shown the potential to improve lipid levels. In this review, recent advances in various important metabolic aspects of M. circinelloides have been discussed. Furthermore, the potential applications of M. circinelloides in the fields of antioxidants, nutraceuticals, bioremediation, ethanol production, and carotenoids like beta carotene and astaxanthin having significant nutritional value are also deliberated. The online version contains supplementary material available at 10.1186/s12934-022-01758-9.
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影响因子：
11.4
作者：
Goncalves, Cristiana;Lopes, Marlene;Belo, Isabel
通讯作者：
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影响因子：
4.1
作者：
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影响因子：
7.4
作者：
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de Castro, Heizir F.
影响因子：
2.4
作者：
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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