Measurement of the Total Lung Volume Using an Adjusted Single-Breath Helium Dilution Method in Patients With Obstructive Lung Disease.
Measurement of the Total Lung Volume Using an Adjusted Single-Breath Helium Dilution Method in Patients With Obstructive Lung Disease.
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使用调整后的单次呼吸氦气稀释法测量阻塞性肺病患者的总肺容量
DOI：
10.3389/fmed.2021.737360
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发表时间：
2021
影响因子：
3.9
通讯作者：
Huang G
中科院分区：
文献类型：
--
作者：
Liu Q;Zhou L;Feng P;Liu J;Shen B;Huang L;Wang Y;Zou Y;Xia Y;Huang G
背景资料：全身体积描记术（WBP）是测量肺容量的金标准，但其临床应用受到限制，因为它需要昂贵的设备并且使用不简单。研究表明，临床实践中常用的单次呼吸氦稀释（SBHD）方法显著低估了阻塞性肺疾病（OLD）患者的肺容量。通过比较SBHD法和WBP法测量肺容积的差异，建立SBHD法测量不同严重程度OLD患者肺总容积的校正方程。研究方法：在同时接受SBHD和WBP的628例OLD患者中，2018年1月至2019年11月期间入组的407例患者属于培训组，2019年12月至2020年12月期间入组的221例患者属于前瞻性验证队列。将多元线性回归方程用于训练组中的数据，以建立SBHD的校正方程，从而确定总肺体积，并在前瞻性验证队列中对此进行验证。结果如下：SBHD法测定的总肺容量（TLC）与WBP法测定的TLC呈中度正相关（r = 0.701; P < 0.05），TLC（SBHD）与TLC（WBP）的差值（ΔTLC）与梗阻程度有关。随着梗阻严重程度的增加，SBHD法低估了TLC。我们建立了以下校正方程：TLC（校正SBHD）（L）= −0.669 + 0.756*TLC（SBHD）（L）- 0.047* FEV 1FVC +0.039* 身高（cm）-0.009 * 体重（kg）（r2 = 0.753，校正r2 = 0.751）。接下来，我们在验证队列中验证了这个方程。经校正后，TLC（校正SBHD）与TLC（WBP）在梗阻程度组间差异无统计学意义（P > 0.05）。结论：SBHD方法与WBP测量肺总容量相关，但SBHD方法在确定阻塞性肺疾病患者的肺总容量方面存在局限性。本文建立了一个有效可靠的校正方程，以便用SBHD方法准确地评估OLD患者的总肺容量。
Background: Whole-body plethysmography (WBP) is the gold standard for measuring lung volume, but its clinical application is limited as it requires expensive equipment and is not simple to use. Studies have shown that the single-breath helium dilution (SBHD) method, which is commonly used in clinical practice, significantly underestimates lung volume in patients with obstructive lung disease (OLD). By comparing the differences in lung volume measured using SBHD and WBP, we aimed to establish a correction equation for the SBHD method to determine the total lung volume in patients with OLD of different severities. Methods: From 628 patients with OLD simultaneously subjected to SBHD and WBP, 407 patients enrolled between January 2018 and November 2019 were in the training group and 221 enrolled between December 2019 and December 2020 were in the prospective verification cohort. The multiple linear regression equation was used for data in the training group to establish a correction equation for SBHD to determine the total lung volume, and this was validated in the prospective validation cohort. Results: There was a moderate positive correlation between total lung capacity (TLC) determined using the SBHD [TLC (SBHD)] and WBP methods [TLC (WBP)] (r = 0.701; P < 0.05), and the differences between TLC (SBHD) and TLC (WBP) (ΔTLC) were related to the severity of obstruction. As the severity of obstruction increased, the TLC was underestimated by the SBHD method. We established the following correction equation: TLC (adjusted SBHD) (L) = −0.669 + 0.756*TLC(SBHD)(L) – 0.047*FEV1FVC+0.039*height (cm)–0.009*weight(kg)(r2 = 0.753 and adjusted r2 = 0.751). Next, we validated this equation in the validation cohort. With the correction equation, no statistical difference was observed between TLC (adjusted SBHD) and TLC (WBP) among the obstruction degree groups (P > 0.05). Conclusions: The SBHD method is correlated with WBP to measure the total lung volume, but the SBHD method presents limitations in determining the total lung volume in patients with obstructive lung disease. Here, we established an effective and reliable correction equation in order to accurately assess the total lung volume of patients with OLD using the SBHD method.
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影响因子：
2.3
作者：
Milite, Fulvia;Lederer, David J.;Weingarten, Jeremy A.;Fani, Pauline;Mooney, Anne M.;Basner, Robert C.
通讯作者：
Basner, Robert C.
DOI：
10.1164/arrd.1978.118.4.685
发表时间：
1978-01-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
BROWN, R;INGRAM, RH;MCFADDEN, ER
通讯作者：
MCFADDEN, ER
影响因子：
5
作者：
Kauczor, HU;Heussel, CP;Thelen, M
通讯作者：
Thelen, M
影响因子：
3.3
作者：
Ma, Baoshun;Bates, Jason H. T.
通讯作者：
Bates, Jason H. T.
DOI：
10.1164/arrd.1983.128.1.54
发表时间：
1983-01-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
SHORE, SA;HUK, O;MARTIN, JG
通讯作者：
MARTIN, JG