Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.
Prospective study of chronotype and incident depression among middle- and older-aged women in the Nurses' Health Study II.
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DOI：
10.1016/j.jpsychires.2018.05.022
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发表时间：
2018-08
影响因子：
4.8
通讯作者：
Schernhammer ES
中科院分区：
文献类型：
--
作者：
Vetter C;Chang SC;Devore EE;Rohrer F;Okereke OI;Schernhammer ES
以前的横断面研究表明，作为一个晚时钟型与抑郁症和抑郁症状有关，但缺乏前瞻性数据。我们在护士健康研究II队列中的32，470名女性参与者中检查了生理时钟类型和事件抑郁症（定义为自我报告的医生/临床医生诊断的抑郁症或抗抑郁药物使用）之间的关联，这些女性参与者自我报告了他们的生理时钟类型（早期，中期或晚期），并且在2009年基线时没有抑郁症（平均年龄：55岁）。女性在2011年和2013年更新了两年一次的问卷调查中的抑郁状态。我们使用多变量（MV）调整的考克斯比例风险模型来估计不同时间类型（即，早期、中期和晚期时间型）。在为期4年的随访期间，我们观察到该队列中有2，581例抑郁症事件。与中间时间型相比，早时间型在MV调整后抑郁风险适度降低（MVHR=0.88，95%CI=0.81-0.96），而晚时间型的风险相似，为1.06（95%CI=0.93-1.20）;不同时间型的总体趋势具有统计学显著性（ptrend<0.01）。当我们将分析限制在平均睡眠时间（7 - 8小时/天）且基线时没有夜班轮换史的女性时，结果相似。我们的研究结果表明，时钟类型可能会影响抑郁症的风险在中老年妇女。需要进一步的研究来证实这些发现，并检查环境和遗传因素的作用，以进一步了解时间型在情绪障碍病因学中的作用。
Prior cross-sectional studies have suggested that being a late chronotype is associated with depression and depressive symptoms, but prospective data are lacking. We examined the association between chronotype and incident depression (defined as self-reported physician/clinician-diagnosed depression or antidepressant medication use) in 32,470 female participants of the Nurses’ Health Study II cohort who self-reported their chronotype (early, intermediate or late) and were free of depression at baseline in 2009 (average age: 55 yrs). Women updated their depression status on biennial questionnaires in 2011 and 2013. We used multivariable (MV)-adjusted Cox proportional hazards models to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) for incident depression across chronotype categories (i.e., early, intermediate, and late chronotypes). Across a follow-up period of 4 years, we observed 2,581 cases of incident depression in this cohort. Compared to intermediate chronotypes, early chronotypes had a modestly lower risk of depression after MV adjustment (MVHR=0.88, 95%CI=0.81–0.96), whereas late chronotypes had a similar risk of 1.06 (95%CI=0.93–1.20); the overall trend across chronotype categories was statistically significant (ptrend<0.01). Results were similar when we restricted analyses to women who reported average sleep durations (7 to 8h/day) and no history of rotating night shift work at baseline. Our results suggest that chronotype may influence the risk of depression in middle- to older-aged women. Additional studies are needed to confirm these findings and examine roles of both environmental and genetic factors to further our understanding of the role of chronotype in the etiology of mood disorders.
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影响因子：
2.8
作者：
Arendt, J
通讯作者：
Arendt, J
影响因子：
7.2
作者：
Maglione, Jeanne E.;Nievergelt, Caroline M.;Tranah, Gregory J.
通讯作者：
Tranah, Gregory J.
影响因子：
5.6
作者：
Chan, Joey Wing Yan;Lam, Siu Ping;Wing, Yun-Kwok
通讯作者：
Wing, Yun-Kwok
DOI：
10.1073/pnas.0707772105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Brown, Steven A.;Kunz, Dieter;Kramer, Achim
通讯作者：
Kramer, Achim
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE