Developmental heatmaps of brain functional connectivity from newborns to 6-year-olds.
Developmental heatmaps of brain functional connectivity from newborns to 6-year-olds.
复制标题
从新生儿到 6 岁儿童大脑功能连接的发育热图。
DOI：
10.1016/j.dcn.2021.100976
复制
发表时间：
2021-08
影响因子：
4.7
通讯作者：
Gao W
中科院分区：
文献类型：
--
作者：
Chen H;Liu J;Chen Y;Salzwedel A;Cornea E;Gilmore JH;Gao W
热图量化了功能连接的发育变化程度。在产后第一年比第二年观察到更多的变化，这是由女孩推动的。与任何其他年龄段相比，2-4岁的变化最大。边缘和皮层下区域比初级感觉区域表现出更多的变化。在验证过程中发现了功能连接的一致轨迹。不同的功能网络在整个发育过程中表现出不同的纵向轨迹，但整个大脑功能连接动态的时间轴仍有待阐明。在这里，我们使用静息态功能磁共振成像来研究在生命的前六年中功能连接的体素水平变化的发展。在全球范围内，我们发现功能连接的发育变化是非线性的，出生后第一年的变化比第二年多，其次是2-4岁和4-6岁的最显著变化。然而，在第一年和第二年之间观察到的总体差异似乎是由女孩造成的。边缘和皮层下区域始终表现出最大的变化，而初级感觉区是最稳定的。这些模式在足月和早产亚组中是一致的。验证随机划分的子样本，以及在一个独立的横截面样本显示全球模式与主要结果一致。总的来说，衍生的发育热图揭示了在生命的前6年期间功能电路发展的新动力学。
Heatmaps quantify degrees of developmental changes in functional connectivity. More changes are observed in the first than second postnatal year, driven by girls. Most change is observed from ages 2–4 compared with any other age span. Limbic and subcortical areas show more changes than primary sensory regions. Consistent trajectories of functional connectivity are found across validations. Different functional networks exhibit distinct longitudinal trajectories throughout development, but the timeline of the dynamics of functional connectivity across the whole brain remains to be elucidated. Here we used resting-state fMRI to investigate the development of voxel-level changes in functional connectivity across the first six years of life. Globally, we found that developmental changes in functional connectivity are nonlinear with more changes during the first postnatal year than the second, followed by most significant changes from ages 2–4 and from ages 4–6. However, the overall global difference observed between the first and second year appears to have been driven by girls. Limbic and subcortical areas consistently demonstrated the most substantial changes, whereas primary sensory areas were the most stable. These patterns were consistent in full-term and preterm subgroups. Validation on randomly divided subsamples as well as in an independent cross-sectional sample revealed global patterns consistent with the main results. Overall, the derived developmental heatmaps reveal novel dynamics underlying functional circuit development during the first 6 years of life.
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DOI：
10.1038/nrn.2018.1
发表时间：
2018-02-16
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Gilmore JH;Knickmeyer RC;Gao W
通讯作者：
Gao W
早产儿大脑连接组学分析揭示功能网络分离的早期发展
影响因子：
3.7
作者：
Cao, Miao;He, Yong;Huang, Hao
通讯作者：
Huang, Hao
影响因子：
3.7
作者：
Fransson, Peter;Aden, Ulrika;Lagercrantz, Hugo
通讯作者：
Lagercrantz, Hugo
影响因子：
6.6
作者：
Fiske, Abigail;Holmboe, Karla
通讯作者：
Holmboe, Karla
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y