Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system.
Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system.
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DOI：
10.1111/j.1582-4934.2007.00001.x
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发表时间：
2007-01
影响因子：
5.3
通讯作者：
Schieker M
中科院分区：
文献类型：
--
作者：
Docheva D;Popov C;Mutschler W;Schieker M
成人组织中间充质干细胞（MSC）的鉴定及其自我更新和多谱系分化能力的揭示为基于细胞的再生和组织工程提供了令人兴奋的前景。尽管有大量描述 MSC 的数据，但仍然缺乏有关控制其粘附和迁移的分子机制的信息。在这项工作中，我们将回顾有关整合素和其他在 MSC 上表达的粘附分子的知识现状。讨论的主题包括间充质干细胞的特征及其临床应用、整合素及其在细胞基质附着和迁移中的核心作用，以及对动员、分化和对肿瘤发展的贡献的评论。最后，通过了解 MSC 附着和迁移的复杂而基本的途径，有可能调整在再生疗法中有效和安全使用 MSC 的策略。
The identification of mesenchymal stem cells (MSCs) in adult human tissues and the disclosure of their self-renew-al and multi-lineage differentiation capabilities have provided exciting prospects for cell-based regeneration and tis-sue engineering. Although a considerable amount of data is available describing MSCs, there is still lack of information regarding the molecular mechanisms that govern their adhesion and migration. In this work, we will review the current state of knowledge on integrins and other adhesion molecules found to be expressed on MSCs. The dis-cussed topics include the characteristics of MSCs and their clinical applications, integrins and their central role in cell-matrix attachment and migration, and comments on mobilization, differentiation and contribution to tumour development. Finally, by understanding the complex and fundamental pathways by which MSCs attach and migrate, it might be possible to fine-tune the strategies for effective and safe use of MSCs in regenerative therapies.
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DOI：
10.1111/j.1749-6632.1995.tb31044.x
发表时间：
1995-01-01
期刊：
BONE MARROW TRANSPLANTATION: FOUNDATIONS FOR THE 21ST CENTURY
影响因子：
--
作者：
Clark, BR;Keating, A
通讯作者：
Keating, A
影响因子：
56.9
作者：
Cukierman, E;Pankov, R;Yamada, KM
通讯作者：
Yamada, KM
DOI：
10.1159/000092971
发表时间：
2006-01-01
期刊：
INFECTION AND INFLAMMATION : IMPACTS ON ONCOGENESIS
影响因子：
--
作者：
Dittmar, Thomas;Seidel, Jeanette;Niggemann, Bernd
通讯作者：
Niggemann, Bernd
影响因子：
2.9
作者：
Grayson, WL;Ma, T;Bunnell, B
通讯作者：
Bunnell, B
影响因子：
11.4
作者：
De Arcangelis, A;Georges-Labouesse, E
通讯作者：
Georges-Labouesse, E