Molecular mechanisms involved in Bacillus subtilis biofilm formation.

Molecular mechanisms involved in Bacillus subtilis biofilm formation.
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DOI:
10.1111/1462-2920.12527
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发表时间:
2015-03
影响因子:
5.1
通讯作者:
Lopez D
Lopez D
中科院分区:
生物学2区
文献类型:
--
作者:
Mielich-Süss B;Lopez D

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生物膜是自然环境中细菌的主要生活方式,它们以许多不同的方式严重影响我们的社会。因此,生物膜形成是微生物学中越来越感兴趣的主题,并且目前研究了不同的细菌模型以更好地理解细菌构建生物膜所经历的分子策略。其中,土壤细菌枯草芽孢杆菌的生物膜通常用于此目的。枯草芽孢杆菌生物膜显示出显著的结构特征,这是群落内细胞特化和细胞间通讯的复杂程序的结果。许多实验室正试图解开生物膜的形态特征的生物学作用,以及探索细胞分化的分子基础。在这篇综述中,我们提出了一个一般的观点,目前的知识状态的生物膜形成在B。枯草杆菌。特别是,特别强调总结该领域的最新发现,并将其整合到这些真正复杂的微生物群落的总体视图中。
Biofilms are the predominant lifestyle of bacteria in natural environments, and they severely impact our societies in many different fashions. Therefore, biofilm formation is a topic of growing interest in microbiology, and different bacterial models are currently studied to better understand the molecular strategies that bacteria undergo to build biofilms. Among those, biofilms of the soil-dwelling bacterium Bacillus subtilis are commonly used for this purpose. Bacillus subtilis biofilms show remarkable architectural features that are a consequence of sophisticated programs of cellular specialization and cell-cell communication within the community. Many laboratories are trying to unravel the biological role of the morphological features of biofilms, as well as exploring the molecular basis underlying cellular differentiation. In this review, we present a general perspective of the current state of knowledge of biofilm formation in B. subtilis. In particular, a special emphasis is placed on summarizing the most recent discoveries in the field and integrating them into the general view of these truly sophisticated microbial communities.
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