Chronic stress impairs prefrontal cortex-dependent response inhibition and spatial working memory.
Chronic stress impairs prefrontal cortex-dependent response inhibition and spatial working memory.
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慢性应力会损害前额叶皮层依赖性反应抑制和空间工作记忆。
DOI：
10.1037/a0029642
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发表时间：
2012-10
影响因子：
1.9
通讯作者：
Conrad CD
中科院分区：
文献类型：
--
作者：
Mika A;Mazur GJ;Hoffman AN;Talboom JS;Bimonte-Nelson HA;Sanabria F;Conrad CD
慢性应激导致前额叶皮层（PFC）的神经化学和结构改变，这与PFC介导的行为缺陷相对应。本研究探讨了慢性束缚应激对反应抑制（使用反应抑制任务，固定最小间隔强化计划，或FMI）和工作记忆（使用径向臂水迷宫，RAWM）的影响。成年雄性Sprague道利大鼠首先在RAWM上训练，随后在FMI上训练。在获得FMI后，将大鼠分配到束缚应激（6 h/d/28 d，在丝网束缚器中）或对照条件。在慢性应激后，立即对大鼠进行FMI测试，随后进行RAWM测试。FMI的结果表明，慢性应激降低反应抑制能力和动机，启动任务的选择性条件下，食物奖励时，没有获得在前面的试验。RAWM的结果表明，慢性应激在不改变先前巩固的参考记忆的情况下产生短暂的工作记忆缺陷。FMI的行为措施未能与RAWM的指标，除了一个在FMI定时精度的变化呈负相关的变化，在RAWM工作记忆错误的控制，这一发现是没有观察到慢性压力。Fisher的r到z转换显示，对照组和应激组之间的相关系数无显著差异。这些发现首次表明，慢性应激会损害反应抑制和工作记忆，这两种行为在慢性应激后从未在同一动物中进行过直接比较，使用FMI（一种食欲任务）和RAWM（一种非食欲任务）。
Chronic stress leads to neurochemical and structural alterations in the prefrontal cortex (PFC) that correspond to deficits in PFC-mediated behaviors. The present study examined the effects of chronic restraint stress on response inhibition (using a response-withholding task, fixed-minimum interval schedule of reinforcement, or FMI), and working memory (using a radial arm water maze, RAWM). Adult male Sprague Dawley rats were first trained on the RAWM and subsequently trained on FMI. Following acquisition of FMI, rats were assigned to a restraint stress (6h/d/28d in wire mesh restrainers) or control condition. Immediately after chronic stress, rats were tested on FMI and subsequently on RAWM. FMI results suggest that chronic stress reduces response inhibition capacity and motivation to initiate the task on selective conditions when food reward was not obtained on the preceding trial. RAWM results suggest that chronic stress produces transient deficits in working memory without altering previously consolidated reference memory. Behavioral measures from FMI failed to correlate with metrics from RAWM except for one in which changes in FMI timing precision negatively correlated with changes in RAWM working memory errors for the controls, a finding that was not observed following chronic stress. Fisher’s r to z transformation revealed no significant differences between control and stress with correlation coefficients. These findings are the first to show that chronic stress impairs both response inhibition and working memory, two behaviors that have never been direct compared within the same animals following chronic stress, using FMI, an appetitive task, and RAWM, a non-appetitive task.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
3.2
作者：
Alexander, Jessica K.;Hillier, Ashleigh;Beversdorf, David Q.
通讯作者：
Beversdorf, David Q.
影响因子：
8.2
作者：
Braver, TS;Barch, DA
通讯作者：
Barch, DA
DOI：
10.1177/1534582302001003001
发表时间：
2002-09-01
期刊：
Behavioral and cognitive neuroscience reviews
影响因子：
--
作者：
Finn, Peter R
通讯作者：
Finn, Peter R
影响因子：
3.3
作者：
Broersen, LM;Uylings, HBM
通讯作者：
Uylings, HBM