White matter pathology isolates the hippocampal formation in Alzheimer's disease.
White matter pathology isolates the hippocampal formation in Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2008.03.013
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发表时间：
2010-02
影响因子：
4.2
通讯作者：
Rosas, H. D.
中科院分区：
文献类型：
--
作者：
Salat, D. H.;Tuch, D. S.;van der Kouwe, A. J. W.;Greve, D. N.;Pappu, V.;Lee, S. Y.;Hevelone, N. D.;Zaleta, A. K.;Growdon, J. H.;Corkin, S.;Fischl, B.;Rosas, H. D.
关键词：
先前的研究表明，阿尔茨海默病（AD）的记忆功能障碍伴随着内侧颞叶（MTL）灰质的明显皮层病理。相比之下，与MTL相关的白质（WM）通路的变化很少被研究。我们使用弥散张量成像（DTI）来检查AD患者WM组织变化的区域模式。阿尔茨海默病的扩散特性改变发生在几个区域，包括海马旁WM，以及与MTL有直接和间接连接的区域。测量的一部分变化，包括海马旁WM的影响，与海马体积测量的灰质变性无关。对独特扩散参数（包括各向异性、轴向和径向扩散率）的区域变化的检查显示，不同区域的改变可能源于潜在病理的差异，海马旁WM可能存在髓鞘特异性病理。这些结果表明，与海马形成的新皮质连接的恶化部分是由关键MTL和相关纤维通路的退化引起的。
Prior work has demonstrated that the memory dysfunction of Alzheimer’s disease (AD) is accompanied by marked cortical pathology in medial temporal lobe (MTL) gray matter. In contrast, changes in white matter (WM) of pathways associated with the MTL have rarely been studied. We used diffusion tensor imaging (DTI) to examine regional patterns of WM tissue changes in individuals with AD. Alterations of diffusion properties with AD were found in several regions including parahippocampal WM, and in regions with direct and secondary connections to the MTL. A portion of the changes measured, including effects in the parahippocampal WM, were independent of gray matter degeneration as measured by hippocampal volume. Examination of regional changes in unique diffusion parameters including anisotropy and axial and radial diffusivity demonstrated distinct zones of alterations, potentially stemming from differences in underlying pathology, with a potential myelin specific pathology in the parahippocampal WM. These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
4
作者：
de Jager, CA;Budge, MM;Clarke, R
通讯作者：
Clarke, R
影响因子：
14.5
作者：
ENGLUND, E;BRUN, A;ALLING, C
通讯作者：
ALLING, C
DOI：
10.1176/appi.neuropsych.16.4.488
发表时间：
2004-09-01
影响因子：
2.9
作者：
Hirono, N;Hashimoto, M;Mori, E
通讯作者：
Mori, E
影响因子：
5.1
作者：
Chen Shao-qiong;Kang Zhuang;Zou Yan
通讯作者：
Zou Yan