Mesenchymal stem cells: amazing remedies for bone and cartilage defects.
Mesenchymal stem cells: amazing remedies for bone and cartilage defects.
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DOI：
10.1186/s13287-020-02001-1
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发表时间：
2020-11-23
影响因子：
7.5
通讯作者：
Razmkhah M
中科院分区：
文献类型：
--
作者：
Kangari P;Talaei-Khozani T;Razeghian-Jahromi I;Razmkhah M
骨骼疾病是影响全球数百万人的主要致残因素之一。干细胞用于组织修复在包括骨骼疾病在内的多个医学领域带来了诸多希望。间充质干细胞（MSCs）是具有中胚层和神经嵴起源的多能基质细胞。这些细胞是再生医学中最具吸引力的候选细胞之一，它们可通过归巢、血管生成、分化以及对炎症状态的反应等多种机制，有助于骨骼疾病的修复和再生。研究最广泛的间充质干细胞来源是骨髓（BM）、脂肪组织、肌肉、脐带（UC）、脐带血（UCB）、胎盘（PL）、沃顿胶（WJ）和羊水。这些细胞在体外能够分化为成骨细胞、软骨细胞、脂肪细胞和肌细胞。从不同来源获取的间充质干细胞具有分泌多种不同细胞因子、生长因子和趋化因子的不同能力。据信，不同来源的间充质干细胞在修复或重塑受损骨骼组织方面的有益效果并不相同。因此，对间充质干细胞分泌组的差异鉴定使我们能够在考虑不同来源的情况下，对骨骼疾病做出最佳选择。这篇综述讨论并比较了来自不同来源的间充质干细胞对骨和软骨疾病的治疗能力。
Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skeletal disorders. Mesenchymal stem cells (MSCs) are multipotent stromal cells with mesodermal and neural crest origin. These cells are one of the most attractive candidates in regenerative medicine, and their use could be helpful in repairing and regeneration of skeletal disorders through several mechanisms including homing, angiogenesis, differentiation, and response to inflammatory condition. The most widely studied sources of MSCs are bone marrow (BM), adipose tissue, muscle, umbilical cord (UC), umbilical cord blood (UCB), placenta (PL), Wharton’s jelly (WJ), and amniotic fluid. These cells are capable of differentiating into osteoblasts, chondrocytes, adipocytes, and myocytes in vitro. MSCs obtained from various sources have diverse capabilities of secreting many different cytokines, growth factors, and chemokines. It is believed that the salutary effects of MSCs from different sources are not alike in terms of repairing or reformation of injured skeletal tissues. Accordingly, differential identification of MSCs’ secretome enables us to make optimal choices in skeletal disorders considering various sources. This review discusses and compares the therapeutic abilities of MSCs from different sources for bone and cartilage diseases.
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影响因子：
14
作者：
Bowles RD;Setton LA
通讯作者：
Setton LA
将人类脂肪来源的间充质干细胞接种到胶原羟基磷灰石支架中，在植入小鼠体内后可促进骨增强。
影响因子：
4.6
作者：
Calabrese G;Giuffrida R;Forte S;Fabbi C;Figallo E;Salvatorelli L;Memeo L;Parenti R;Gulisano M;Gulino R
通讯作者：
Gulino R
影响因子：
4.1
作者：
An, Jee Hyun;Park, Hyojung;Shin, Chan Soo
通讯作者：
Shin, Chan Soo
DOI：
10.18632/oncoscience.421
发表时间：
2018-05
期刊：
Oncoscience
影响因子：
--
作者：
Behera J;Tyagi N
通讯作者：
Tyagi N
影响因子：
3
作者：
Blanco, Juan F.;Graciani, Ignacio F.;del Canizo, Maria-Consuelo
通讯作者：
del Canizo, Maria-Consuelo