Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI.
Identify changes of brain regional homogeneity in bipolar disorder and unipolar depression using resting-state FMRI.
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DOI：
10.1371/journal.pone.0079999
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Huang Z
中科院分区：
文献类型：
--
作者：
Liang MJ;Zhou Q;Yang KR;Yang XL;Fang J;Chen WL;Huang Z
确定双相情感障碍（BD）和单相抑郁症（UD）患者脑激活模式的变化。对16名健康对照、17名BD和16名UD患者进行静息状态fMRI扫描。以逐体素方式进行归一化区域均匀性（ReHo）的T检验。使用组合阈值α = 0.05、最小簇体积V = 10503 mm3（389体素）来确定组间ReHo差异。 UD组左侧枕中叶、右侧顶下小叶、右侧楔前叶和左侧脑回ReHo增强，左侧枕旁回、右侧中央前回、左侧中央后回、左侧中央前回和左侧扣带回ReHo减弱。BD组右侧岛叶皮质、左侧额中回、左侧楔前叶、左侧枕叶、左侧顶叶、左侧额上级回、左侧丘脑ReHo增加，右侧小脑前叶、脑桥、右侧中央前回、左侧中央后回、左侧额下回、右侧扣带回ReHo减少。UD组与BD组的ReHo谱有一定的重叠，但BD组丘脑的ReHo谱有明显差异。静息态功能磁共振成像和ReHo映射是一个很有前途的工具，以协助检测功能缺陷和区分BD和UD的临床和病理生理体征。
To identify changes in brain activation patterns in bipolar disorder (BD) and unipolar depression (UD) patients. Resting-state fMRI scans of 16 healthy controls, 17 BD and 16 UD patients were obtained. T-test of normalized regional homogeneity (ReHo) was performed in a voxel-by-voxel manner. A combined threshold of á = 0.05, minimum cluster volume of V = 10503 mm3 (389 voxels) were used to determine ReHo differences between groups. In UD group, fMRI revealed ReHo increases in the left middle occipital lobe, right inferior parietal lobule, right precuneus and left convolution; and ReHo decreases in the left parahippocampalgyrus, right precentralgyrus, left postcentralgyrus, left precentralgyrus and left cingulated. In BD group, ReHo increases in the right insular cortex, left middle frontal gyrus, left precuneus, left occipital lobe, left parietal, left superior frontal gyrus and left thalamus; and ReHo decreases in the right anterior lobe of cerebellum, pons, right precentralgyrus, left postcentralgyrus, left inferior frontal gyrus, and right cingulate. There were some overlaps in ReHo profiles between UD and BD groups, but a marked difference was seen in the thalamus of BD. The resting-state fMRI and ReHo mapping are a promising tool to assist the detection of functional deficits and distinguish clinical and pathophysiological signs of BD and UD.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
6.6
作者：
Graff-Guerrero, A;González-Olvera, J;García-Reyna, JC
通讯作者：
García-Reyna, JC
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
3.8
作者：
Bowden, CL
通讯作者：
Bowden, CL
影响因子：
7.2
作者：
Kenny, Eva R.;O'Brien, John T.;Blamire, Andrew M.
通讯作者：
Blamire, Andrew M.