Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis.
Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis.
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DOI：
10.1186/s13075-017-1411-0
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发表时间：
2017-09-12
影响因子：
4.9
通讯作者：
Kaneko K
中科院分区：
文献类型：
--
作者：
Hada S;Ishijima M;Kaneko H;Kinoshita M;Liu L;Sadatsuki R;Futami I;Yusup A;Takamura T;Arita H;Shiozawa J;Aoki T;Takazawa Y;Ikeda H;Aoki S;Kurosawa H;Okada Y;Kaneko K
内侧半月板挤压（MME）与内侧膝关节骨性关节炎（OA）的进展有关，但没有或很少有关于MME与骨赘之间关系的信息，骨赘存在于软骨和骨部分。由于x线摄影或常规磁共振成像（MRI）对骨赘软骨部分的检测能力有限，骨赘的发展速度和大小似乎被低估了。由于T2成像MRI可以使我们评估骨赘的软骨部分，我们旨在通过常规和T2成像MRI检查MME与oa相关变化（包括骨赘）之间的关系。对50例早期膝关节OA患者进行了检查。除MME外，mri检测到的oa相关改变根据全器官磁共振成像评分进行评估。测量内侧半月板和骨赘的T2值。对终末期膝关节OA患者手术切除的骨赘进行组织学分析，并与x线摄影和MRI结果进行比较。在98%的早期膝关节OA患者中，T2定位MRI检测到内侧骨赘，尽管常规MRI和x线摄影的检出率分别为48%和40%。在OA相关的变化中，经多元logistic回归分析，早期膝关节OA患者胫骨内侧骨刺距离与MME的关系最为密切（β = 0.711, p < 0.001）。早期膝关节OA患者内侧半月板T2值与MME直接相关，MME≥3 mm （r = 0.58, p = 0.003）。通过对终末期膝关节OA患者切除的骨赘进行组织学分析，证实了T2定位MRI骨赘评估的准确性。我们的研究表明，T2定位MRI评估的胫骨内侧骨赘常见于早期膝关节OA患者，与MME密切相关，且MME与半月板退变呈正相关。
Medial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information is available for relationships between MME and osteophytes, which are found in cartilage and bone parts. Because of the limitation in detectability of the cartilage part of osteophytes by radiography or conventional magnetic resonance imaging (MRI), the rate of development and size of osteophytes appear to have been underestimated. Because T2 mapping MRI may enable us to evaluate the cartilage part of osteophytes, we aimed to examine the association between MME and OA-related changes, including osteophytes, by using conventional and T2 mapping MRI. Patients with early-stage knee OA (n = 50) were examined. MRI-detected OA-related changes, in addition to MME, were evaluated according to the Whole-Organ Magnetic Resonance Imaging Score. T2 values of the medial meniscus and osteophytes were measured on T2 mapping images. Osteophytes surgically removed from patients with end-stage knee OA were histologically analyzed and compared with findings derived by radiography and MRI. Medial side osteophytes were detected by T2 mapping MRI in 98% of patients with early-stage knee OA, although the detection rate was 48% by conventional MRI and 40% by radiography. Among the OA-related changes, medial tibial osteophyte distance was most closely associated with MME, as determined by multiple logistic regression analysis, in the patients with early-stage knee OA (β = 0.711, p < 0.001). T2 values of the medial meniscus were directly correlated with MME in patients with early-stage knee OA, who showed ≥ 3 mm of MME (r = 0.58, p = 0.003). The accuracy of osteophyte evaluation by T2 mapping MRI was confirmed by histological analysis of the osteophytes removed from patients with end-stage knee OA. Our study demonstrates that medial tibial osteophyte evaluated by T2 mapping MRI is frequently observed in the patients with early-stage knee OA, showing close association with MME, and that MME is positively correlated with the meniscal degeneration.
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影响因子：
4.9
作者：
Ding C;Martel-Pelletier J;Pelletier JP;Abram F;Raynauld JP;Cicuttini F;Jones G
通讯作者：
Jones G
影响因子：
27.4
作者：
Davidson, E. N. Blaney;Vitters, E. L.;van den Berg, W. B.
通讯作者：
van den Berg, W. B.
影响因子：
4.8
作者：
Bhatia, Sanjeev;LaPrade, Christopher M.;LaPrade, Robert F.
通讯作者：
LaPrade, Robert F.
影响因子：
3.9
作者：
Keshava, S. N.;Gibikote, S. V.;Doria, A. S.
通讯作者：
Doria, A. S.
影响因子：
19.7
作者：
Crema, Michel D.;Roemer, Frank W.;Guermazi, Ali
通讯作者：
Guermazi, Ali