High-frequency stimulation induces axonal conduction block without generating initial action potentials.
High-frequency stimulation induces axonal conduction block without generating initial action potentials.
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DOI：
10.1007/s10827-021-00806-4
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发表时间：
2022-05
影响因子：
1.2
通讯作者：
中科院分区：
文献类型：
--
作者：
本模型研究的目的是开发一种新的方法，通过高频双相刺激（HFBS）阻断神经传导，而不产生初始动作电位。一个轴突传导模型，包括离子浓度和膜离子泵被用来分析轴突响应1 kHz HFBS。HFBS的强度以多个步骤增加，同时将强度保持在亚阈值水平以避免产生动作电位。HFBS引起的轴突传导阻滞是指HFBS部位的动作电位传播失败。模拟分析表明，在HFBS过程中，阈值下强度的逐步增加可以成功地阻断轴突传导而不产生初始响应，因为轴突的激发阈值可以通过阈值下HFBS逐渐增加。兴奋阈值增加的机制涉及细胞内和细胞外钠和钾浓度的变化，静息电位的变化，HFBS对钠通道的部分失活和对钾通道的部分激活。当兴奋阈值达到足够的水平时，首先发生急性阻滞，在额外的亚阈值HFBS之后，随后是刺激后阻滞。这项研究表明，在阈下HFBS强度的逐步增加诱导轴突兴奋阈值的逐渐增加，这可能使HFBS阻断神经传导而不产生初始反应。如果这一发现在人体中被证明是正确的，它将显着影响HFBS治疗慢性疼痛的临床应用。
The purpose of this modeling study is to develop a novel method to block nerve conduction by high frequency biphasic stimulation (HFBS) without generating initial action potentials. An axonal conduction model including both ion concentrations and membrane ion pumps is used to analyze the axonal response to 1 kHz HFBS. The intensity of HFBS is increased in multiple steps while maintaining the intensity at a sub-threshold level to avoid generating an action potential. Axonal conduction block by HFBS is defined as the failure of action potential propagation at the site of HFBS. The simulation analysis shows that step-increases in sub-threshold intensity during HFBS can successfully block axonal conduction without generating an initial response because the excitation threshold of the axon can be gradually increased by the sub-threshold HFBS. The mechanisms underlying the increase in excitation threshold involve changes in intracellular and extracellular sodium and potassium concentration, change in the resting potential, partial inactivation of the sodium channel and partial activation of the potassium channel by HFBS. When the excitation threshold reaches a sufficient level, an acute block occurs first and after additional sub-threshold HFBS it is followed by a post-stimulation block. This study indicates that step-increases in sub-threshold HFBS intensity induces a gradual increase in axonal excitation threshold that may allow HFBS to block nerve conduction without generating an initial response. If this finding is proven to be true in human, it will significantly impact clinical applications of HFBS to treat chronic pain.
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DOI：
10.1111/ner.13241
发表时间：
2021-08
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Shapiro K;Guo W;Armann K;Pace N;Shen B;Wang J;Beckel J;de Groat W;Tai C
通讯作者：
Tai C
影响因子：
2.8
作者：
Soin, Amol;Shah, Nemath Syed;Fang, Zi-Ping
通讯作者：
Fang, Zi-Ping
DOI：
10.1111/ner.13501
发表时间：
2023-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Zhong Y;Wang J;Beckel J;de Groat WC;Tai C
通讯作者：
Tai C
影响因子：
3.2
作者：
Yang, Guangning;Xiao, Zhiying;Wang, Jicheng;Shen, Bing;Roppolo, James R.;de Groat, William C.;Tai, Changfeng
通讯作者：
Tai, Changfeng
影响因子：
9.8
作者：
WHITWAM, JG;KIDD, C
通讯作者：
KIDD, C