Chemical mixture exposures during pregnancy and cognitive abilities in school-aged children.
Chemical mixture exposures during pregnancy and cognitive abilities in school-aged children.
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学龄儿童怀孕期间接触化学混合物与认知能力。
DOI：
10.1016/j.envres.2021.111027
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发表时间：
2021-06
影响因子：
8.3
通讯作者：
Braun, Joseph M.
中科院分区：
文献类型：
--
作者：
Kalloo, Geetika;Wellenius, Gregory A.;McCandless, Lawrence;Calafat, Antonia M.;Sjodin, Andreas;Sullivan, Adam J.;Romano, Megan E.;Karagas, Margaret R.;Chen, Aimin;Yolton, Kimberly;Lanphear, Bruce P.;Braun, Joseph M.
孕妇普遍接触化学混合物，可能与儿童期神经发育不良有关。然而，很少有研究探讨妊娠期化学混合物暴露和儿童的认知能力之间的关系。在来自俄亥俄州辛辛那提（2003-2006年入组）的253名孕妇及其子女的队列中，我们定量了血液或尿液中43种金属、邻苯二甲酸盐、苯酚、多溴二苯醚、有机磷和有机氯农药、多氯联苯、全氟烷基物质和环境烟草烟雾的生物标志物浓度。使用k-均值聚类和主成分（PC）分析，我们的特点是孕妇的化学混合物。我们分别在5岁和8岁时使用韦氏学前和小学智力量表III和韦氏儿童智力量表IV评估儿童的认知能力。我们估计了儿童认知能力评分的协变量调整差异]=交叉聚类，并且PC评分和个体生物标志物浓度增加。几何平均生物标志物浓度一般最高，中间和最低的妇女在集群1，2和3，分别。与第3组的儿童相比，第1组和第2组妇女所生的儿童的表现智商得分分别低5.1（95% CI：-9.4，-0.8）和2.0（95% CI：-5.5，1，4）。PC评分和个体化学生物标志物浓度与认知能力无关。在这个队列中，产前接触酚类、某些邻苯二甲酸酯、农药和全氟烷基物质与儿童的认知能力呈负相关，但一些个体化学生物标志物浓度则不然。进一步的研究应该确定这些化学物质对认知的总体影响是否不同于它们的个体影响。
Gestational exposure to chemical mixtures, which is prevalent among pregnant women, may be associated with adverse childhood neurodevelopment. However, few studies have examined relations between gestational chemical mixture exposure and children’s cognitive abilities. In a cohort of 253 pregnant women and their children from Cincinnati, OH (enrolled 2003–2006), we quantified biomarker concentrations of 43 metals, phthalates, phenols, polybrominated diphenyl ethers, organophosphate and organochlorine pesticides, polychlorinated biphenyls, perfluoroalkyl substances, and environmental tobacco smoke in blood or urine. Using k-means clustering and principal component (PC) analysis, we characterized chemical mixtures among pregnant women. We assessed children’s cognitive abilities using the Wechsler Preschool and Primary Scale of Intelligence-III and Wechsler Intelligence Scale for Children-IV at ages 5 and 8 years, respectively. We estimated covariate- adjusted differences in children’s cognitive ability scores ]=cross clusters, and with increasing PC scores and individual biomarker concentrations. Geometric mean biomarker concentrations were generally highest, intermediate, and lowest among women in clusters 1, 2, and 3, respectively. Children born to women in clusters 1 and 2 had 5.1 (95% CI:−9.4,−0.8) and 2.0 (95% CI:−5.5, 1,4) lower performance IQ scores compared to children in cluster 3, respectively. PC scores and individual chemical biomarker concentrations were not associated with cognitive abilities. In this cohort, combined prenatal exposure to phenols, certain phthalates, pesticides, and perfluoroalkyl substances was inversely associated with children’s cognition, but some individual chemical biomarker concentrations were not. Additional studies should determine if the aggregate impact of these chemicals on cognition is different from their individual effects.
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影响因子：
10.4
作者：
Braun JM;Kalkbrenner AE;Just AC;Yolton K;Calafat AM;Sjödin A;Hauser R;Webster GM;Chen A;Lanphear BP
通讯作者：
Lanphear BP
影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
2.6
作者：
Ivanovic, DM;Leiva, BP;Larraín, CG
通讯作者：
Larraín, CG
DOI：
10.1038/sj.jea.7500322
发表时间：
2004-05-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Bravo, R;Caltabiano, LM;Barr, DB
通讯作者：
Barr, DB
影响因子：
3.4
作者：
Gilbert, Mary E.;Rovet, Joanne;Koibuchi, Noriyuki
通讯作者：
Koibuchi, Noriyuki