Control of visual cortical signals by prefrontal dopamine.
Control of visual cortical signals by prefrontal dopamine.
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DOI：
10.1038/nature09995
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发表时间：
2011-05-15
期刊：
影响因子：
64.8
通讯作者：
Moore, Tirin
中科院分区：
文献类型：
--
作者：
Noudoost, Behrad;Moore, Tirin
前额叶皮层（PFC）被认为在自上而下的注意力过程中调节后皮层的感觉信号，但对潜在的神经回路知之甚少。实验和临床证据表明，前额叶多巴胺在认知功能中起重要作用，主要通过D1受体（D1Rs）起作用。在这里，我们发现多巴胺D1Rs介导了视觉皮层内的前额叶信号控制。我们在药理学上改变了PFC额叶视野（FEF）内d1r介导的活性，并测量了其对视觉皮层内神经元反应的影响。这种操作足以提高V4区域神经元的反应幅度、定向选择性和反应可靠性，其效果与已知的自上而下注意的效果相当。观察到的V4信号增强仅限于反应场（RFs）与D1R操作影响的视觉空间部分重叠的神经元。改变D1R或D2R介导的FEF活性增加了跳眼靶选择，但D2R操作没有增强V4信号。我们的研究结果确定了D1Rs在PFC介导视觉皮质信号控制中的作用，并证明了在涉及前额叶多巴胺的精神障碍中，感觉区域内的处理是如何改变的。
The prefrontal cortex (PFC) is thought to modulate sensory signals in posterior cortices during top-down attention, yet little is known about the underlying neural circuitry. Experimental and clinical evidence suggest that prefrontal dopamine plays an important role in cognitive functions, acting predominantly through D1 receptors (D1Rs). Here we show that dopamine D1Rs mediate prefrontal control of signals within visual cortex. We pharmacologically altered D1R-mediated activity within the frontal eye field (FEF) of the PFC and measured its effects on the responses of neurons within visual cortex. This manipulation was sufficient to enhance the response magnitude, orientation selectivity and response reliability of neurons in area V4 to an extent comparable with the known effects of top-down attention. The observed enhancement in V4 signals was restricted to neurons with response fields (RFs) overlapping the part of visual space affected by the D1R manipulation. Altering D1R or D2R-mediated FEF activity increased saccadic target selection, but the D2R manipulation did not enhance V4 signals. Our results identify a role of D1Rs in mediating the control of visual cortical signals by the PFC and demonstrate how processing within sensory areas can be altered in mental disorders involving prefrontal dopamine.
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影响因子：
16.2
作者：
Mitchell, Jude F.;Sundberg, Kristy A.;Reynolds, John H.
通讯作者：
Reynolds, John H.
DOI：
10.1126/science.1171402
发表时间：
2009-05-29
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gregoriou GG;Gotts SJ;Zhou H;Desimone R
通讯作者：
Desimone R
影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.
DOI：
10.1523/jneurosci.4465-09.2009
发表时间：
2009-12-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Armstrong KM;Chang MH;Moore T
通讯作者：
Moore T
影响因子：
25
作者：
Vijayraghavan, Susheel;Wang, Min;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.