Cross-linked demineralized dentin maintains its mechanical stability when challenged by bacterial collagenase.
Cross-linked demineralized dentin maintains its mechanical stability when challenged by bacterial collagenase.
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DOI：
10.1002/jbm.b.31759
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发表时间：
2011-02
影响因子：
3.4
通讯作者：
Wang, Yong
中科院分区：
文献类型：
--
作者：
Xu, Changqi;Wang, Yong
本文研究了非交联型/戊二醛交联型脱矿牙本质在细菌胶原酶作用下的分子结构、失重及力学性能。拉曼光谱证实脱矿牙本质基质经GA处理后发生了交联。同时，经细菌胶原酶作用1周后，交联脱矿牙本质基质的重量无明显变化。然而，未交联牙本质胶原蛋白在降解5小时后几乎下降了45%，19小时后下降了100%。脱矿牙本质基质经交联剂处理后的抗拉强度无明显变化，但硬度较未交联胶原蛋白有较大改善。脱矿牙本质基质经交联后韧性略有下降。重要的是，在对照缓冲液或胶原酶溶液中，与非交联组相比，GA-交联型脱矿牙本质的抗张强度和硬度都没有随着时间的推移而变化。这些结果提示，提高牙本质胶原蛋白的交联度可能是抑制其生物降解，进而提高牙体修复体耐久性的方法之一。
The molecular structure, weight loss and mechanical properties of demineralized dentin of non-crosslinked/crosslinked by glutaraldehyde (GA) were investigated when being challenged by bacterial collagenase solution over time in the present study. Raman spectra proved that cross-linking occurred in demineralized dentin matrices after being treated with GA. Meanwhile, the weight of the cross-linked demineralized dentin matrices didn’t change after being challenged by bacterial collagenase solution up to one week. However, the weight of non-crosslinked dentin collagen fell by almost 45% after degradation for 5 hr, and up to 100% after 19 hr. The tensile strength of demineralized dentin matrices didn’t show a significant change after being crosslinked, while the stiffness of demineralized dentin matrices showed more improvement than that of non-crosslinked collagen. The toughness of demineralized dentin matrices decreased slightly after being crosslinked. Importantly, neither the tensile strength of GA-crosslinked demineralized dentin nor its stiffness changed over time in either control buffer or collagenase solution compared to that of noncrosslinked controls. These results suggested that improving the degree of cross-linking in dentin collagen could be one method to inhibit its biodegradation and further to increase the durability of dental restorations.
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DOI：
10.1002/jmb.b.31022
发表时间：
2008-08-01
影响因子：
3.4
作者：
Bedran-Russo, Ana Karina B.;Pashley, David H.;Miescke, Klaus J.
通讯作者：
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DOI：
10.1163/156856203321142605
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影响因子：
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DOI：
10.1016/s0169-7439(98)00084-7
发表时间：
1998-09-28
影响因子：
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作者：
Leung, AKM;Chau, FT;Shih, TM
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影响因子：
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