Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.
Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure.
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DOI：
10.3390/ijms22147521
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发表时间：
2021-07-14
影响因子：
5.6
通讯作者：
Sundberg EJ
中科院分区：
文献类型：
--
作者：
Nedeljković M;Sastre DE;Sundberg EJ
细菌鞭毛是一种复杂而动态的纳米机器，它推动细菌通过液体。它由基体、钩和长丝组成。鞭毛细丝由数千个拷贝的鞭毛蛋白(Flc)螺旋排列而成，末端是由Flid蛋白的寡聚体组成的丝帽。细丝核心的整体结构在细菌物种中保持不变，而外区表现出高度的可变性，在某些情况下甚至完全不存在。鞭毛组装是一个复杂且耗费能量的过程，由环境刺激触发，因此在转录、翻译和翻译后水平上受到高度调控。除了在运动中发挥作用外，细丝在细菌生存、繁殖和致病的其他几个方面也是至关重要的，如与表面的黏附、毒力因子的分泌和生物膜的形成。此外，由于鞭毛蛋白能够激发强大的免疫反应，它在疫苗开发中具有佐剂的作用。本文就鞭毛蛋白、衣壳蛋白和细丝的结构及其在寄主侵染和侵染过程中的调控作用等方面的最新研究进展作一综述。
The bacterial flagellum is a complex and dynamic nanomachine that propels bacteria through liquids. It consists of a basal body, a hook, and a long filament. The flagellar filament is composed of thousands of copies of the protein flagellin (FliC) arranged helically and ending with a filament cap composed of an oligomer of the protein FliD. The overall structure of the filament core is preserved across bacterial species, while the outer domains exhibit high variability, and in some cases are even completely absent. Flagellar assembly is a complex and energetically costly process triggered by environmental stimuli and, accordingly, highly regulated on transcriptional, translational and post-translational levels. Apart from its role in locomotion, the filament is critically important in several other aspects of bacterial survival, reproduction and pathogenicity, such as adhesion to surfaces, secretion of virulence factors and formation of biofilms. Additionally, due to its ability to provoke potent immune responses, flagellins have a role as adjuvants in vaccine development. In this review, we summarize the latest knowledge on the structure of flagellins, capping proteins and filaments, as well as their regulation and role during the colonization and infection of the host.
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影响因子：
3.1
作者：
Arora, SK;Ritchings, BW;Ramphal, R
通讯作者：
Ramphal, R
影响因子：
5.5
作者：
Biedma, Marina E.;Cayet, Delphine;Sirard, Jean Claude
通讯作者：
Sirard, Jean Claude
影响因子：
3.2
作者：
Bereczk-Tompa, Eva;Posfai, Mihaly;Vonderviszt, Ferenc
通讯作者：
Vonderviszt, Ferenc
影响因子：
3.1
作者：
Arora, SK;Neely, AN;Ramphal, R
通讯作者：
Ramphal, R
DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A