Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
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类驱动蛋白KIF1B基因多态性与肝细胞癌风险
DOI：
10.1371/journal.pone.0062571
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Wang ZC;Gao Q;Shi JY;Yang LX;Zhou J;Wang XY;Shi YH;Ke AW;Shi GM;Ding ZB;Dai Z;Qiu SJ;Fan J
背景 据报道，神经肿瘤中驱动蛋白样蛋白基因 1B (KIF1B) 频繁缺失。最近，一项全基因组关联研究揭示了 KIF1B 基因多态性与肝细胞癌 (HCC) 风险之间的关联，并且几项病例对照研究进一步研究了这种关系。然而，这些研究产生了有争议的结果。因此，我们进行了一项荟萃分析，以更准确地估计 KIF1B 基因多态性与 HCC 风险之间的关联。方法/主要发现 系统检索了 PubMed、EMBASE、ISI Web of Science 和 CNKI 数据库以识别相关研究。总共纳入 5 项研究，包含 13 个队列、5,773 例病例和 6,404 名对照。使用比值比 (OR) 和相应的 95% 置信区间 (CI) 来评估关联的强度。根据种族、样本量和质量得分进行亚组分析。总体而言，KIF1B 基因 rs17401966 的 G 等位基因与 HCC 风险显着降低相关（OR = 0.81，95%CI：0.70–0.93；P = 0.003）。此外，亚组分析显示，KIF1B基因rs17401966位点的G等位基因显着降低了中国人群的肝癌风险（OR = 0.76，95%CI：0.64-0.90；P = 0.002），大样本人群（OR = 0.80，95%CI： 0.73–0.88，P<0.01）和高质量队列（OR = 0.78，95%CI：0.71–0.87，P<0.01）。然而，在小样本队列、低质量分数的研究以及从报告原始发现的研究中排除队列时，没有发现显着的关联。结论/意义 这些研究结果表明，KIF1B 基因 rs17401966 处 G 等位基因的存在可能会降低患 HCC 的风险，并表明 KIF1B 可能在 HCC 的发展中发挥关键作用。更大样本量和不同种族人群的高质量研究对于进一步证实这些发现具有重要价值。
Background Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial results. We therefore performed a meta-analysis to derive a more precise estimation of the association between the KIF1B gene polymorphisms and HCC risk. Methodology/Principal Finding PubMed, EMBASE, the ISI Web of Science and the CNKI databases were systematically searched to identify relevant studies. A total of 5 studies containing 13 cohorts with 5,773 cases and 6,404 controls were included. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Subgroup analyses were conducted based on ethnicities, sample sizes and quality scores. Overall, the G allele at rs17401966 of the KIF1B gene was associated with a significantly decreased risk for HCC (OR = 0.81, 95%CI: 0.70–0.93; P = 0.003). Furthermore, subgroup analyses showed that the G allele at rs17401966 of the KIF1B gene significantly reduced the risk for HCC in Chinese cohorts (OR = 0.76, 95%CI: 0.64–0.90; P = 0.002), large-sample-size cohorts (OR = 0.80, 95%CI: 0.73–0.88, P<0.01) and high-quality cohorts (OR = 0.78, 95%CI: 0.71–0.87, P<0.01). However, no significant associations were found in small-sample-size cohorts, studies with low-quality scores and when excluding the cohorts from the study reporting the original discovery. Conclusion/Significance These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC. High-quality studies with larger sample sizes and different ethnic populations will be of great value to further confirm these findings.
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影响因子：
8.3
作者：
Holroyd-Leduc, JM;Kapral, MK;Tu, JV
通讯作者：
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影响因子：
8.3
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