Mucus barrier, mucins and gut microbiota: the expected slimy partners?
Mucus barrier, mucins and gut microbiota: the expected slimy partners?
复制标题
粘液屏障、粘蛋白和肠道微生物区系：预期的粘液伙伴？
DOI：
10.1136/gutjnl-2020-322260
复制
发表时间：
2020-12
期刊：
影响因子：
24.5
通讯作者：
Cani PD
中科院分区：
文献类型：
--
作者：
Paone P;Cani PD
胃肠道通常被认为是参与食物消化和为身体提供营养以维持正常运转的关键器官。然而，这个系统是由极其复杂的器官组成的。在不同的部分中，肠道被视为与环境接触的一个令人难以置信的表面，并被数以万亿计的肠道微生物所定植。肠道屏障的作用已经被研究了几十年，但保护肠道屏障的确切机制是多种多样的，而且是互补的。其中，粘液屏障的完整性是保护胃肠道的第一道防线之一。在过去，这种“粘稠”的伴侣通常被认为是一种简单的润滑剂，用于促进食物丸和肠道内粪便的进展。从那时起，不同的研究人员取得了重要的进展，目前，这种粘液屏障的调节越来越受到科学界的关注。在影响黏液屏障的因素中，微生物组在驱动黏液变化中起主要作用。此外，我们的饮食习惯（即高脂肪饮食、低纤维/高纤维饮食、食品添加剂、益生菌前）在不同程度上影响黏液。鉴于黏液层与疾病的出现有关，正确的知识是非常必要的。在这里，我们通过关注黏液层的化学组成、微生物群合成和降解的调节以及黏液层在生理和病理情况下的一些特征来讨论黏液层的不同方面。
The gastrointestinal tract is often considered as a key organ involved in the digestion of food and providing nutrients to the body for proper maintenance. However, this system is composed of organs that are extremely complex. Among the different parts, the intestine is viewed as an incredible surface of contact with the environment and is colonised by hundreds of trillions of gut microbes. The role of the gut barrier has been studied for decades, but the exact mechanisms involved in the protection of the gut barrier are various and complementary. Among them, the integrity of the mucus barrier is one of the first lines of protection of the gastrointestinal tract. In the past, this ‘slimy’ partner was mostly considered a simple lubricant for facilitating the progression of the food bolus and the stools in the gut. Since then, different researchers have made important progress, and currently, the regulation of this mucus barrier is gaining increasing attention from the scientific community. Among the factors influencing the mucus barrier, the microbiome plays a major role in driving mucus changes. Additionally, our dietary habits (ie, high-fat diet, low-fibre/high-fibre diet, food additives, pre- probiotics) influence the mucus at different levels. Given that the mucus layer has been linked with the appearance of diseases, proper knowledge is highly warranted. Here, we debate different aspects of the mucus layer by focusing on its chemical composition, regulation of synthesis and degradation by the microbiota as well as some characteristics of the mucus layer in both physiological and pathological situations.
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DOI：
10.1038/nrmicro3552
发表时间：
2016-01
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
Donaldson GP;Lee SM;Mazmanian SK
通讯作者：
Mazmanian SK
影响因子：
24.5
作者：
Cani PD
通讯作者：
Cani PD
影响因子：
64.8
作者：
Chassaing B;Koren O;Goodrich JK;Poole AC;Srinivasan S;Ley RE;Gewirtz AT
通讯作者：
Gewirtz AT
影响因子：
82.9
作者：
Barcena, Clea;Valdes-Mas, Rafael;Lopez-Otin, Carlos
通讯作者：
Lopez-Otin, Carlos
影响因子：
24.5
作者：
Camilleri, Michael
通讯作者：
Camilleri, Michael