Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging.
Probing midbrain dopamine function in pediatric obsessive-compulsive disorder via neuromelanin-sensitive magnetic resonance imaging.
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通过神经素敏感的磁共振成像探测小儿强迫症的中脑多巴胺功能。
DOI：
10.1038/s41380-023-02105-z
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发表时间：
2023-07
影响因子：
11
通讯作者：
Marsh, Rachel
中科院分区：
文献类型：
--
作者：
Pagliaccio, David;Wengler, Kenneth;Durham, Katherine;Fontaine, Martine;Rueppel, Meryl;Becker, Hannah;Bilek, Emily;Pieper, Sarah;Risdon, Caroline;Horga, Guillermo;Fitzgerald, Kate D.;Marsh, Rachel
强迫症(OCD)是一种破坏性的精神疾病，通常在儿童时期开始发作。越来越多的研究强调成人强迫症的多巴胺能改变，但儿科研究受到方法学限制。这是第一次利用神经黑色素敏感的MRI作为强迫症儿童多巴胺能功能的代用品的研究。N = 135名青年(6-14岁)完成了两个部位的高分辨率神经黑色素敏感核磁共振成像；n = 被诊断为强迫症。N = 47名强迫症儿童在接受认知行为治疗后完成了第二次扫描。体素分析发现，强迫症儿童的神经黑色素核磁共振信号高于非强迫症儿童(483个体素，经排列校正的p = 0.018)。在黑质致密部(p = 0.004，Cohen‘s d = 0.5 1)和腹侧被盖区(p = 0.006，d = 0.5 0)均有显著影响。随访分析表明，终生症状越严重(t = −为2.72，p = 为0.009)，病程越长(t = −为2.22，p = 为0.03)，其神经黑素信号越低。尽管治疗后症状显著减少(p <； 0.001，d = 1.44)，但基线和神经黑色素核磁共振信号的改变都与症状改善无关。目前的结果首次证明了神经黑色素-MRI在儿科精神病学中的应用，特别强调了在寻求治疗的患有强迫症的年轻人中脑多巴胺改变的活体证据。神经黑素-MRI可能是随着时间积累变化的指标，在这里，暗示强迫症中的多巴胺过度活动。有证据表明，儿童强迫症的神经黑色素信号增加，但与症状严重程度呈负相关，需要额外的工作来分析潜在的纵向或代偿机制。未来的研究应该探索神经黑色素-MRI生物标记物在发病前识别早期风险、分析强迫症亚型或症状异质性，并探索药物治疗反应的预测。
Obsessive-compulsive disorder (OCD) is an impairing psychiatric condition, which often onsets in childhood. Growing research highlights dopaminergic alterations in adult OCD, yet pediatric studies are limited by methodological constraints. This is the first study to utilize neuromelanin-sensitive MRI as a proxy for dopaminergic function among children with OCD. N = 135 youth (6–14-year-olds) completed high-resolution neuromelanin-sensitive MRI across two sites; n = 64 had an OCD diagnosis. N = 47 children with OCD completed a second scan after cognitive-behavioral therapy. Voxel-wise analyses identified that neuromelanin-MRI signal was higher among children with OCD compared to those without (483 voxels, permutation-corrected p = 0.018). Effects were significant within both the substania nigra pars compacta (p = 0.004, Cohen’s d = 0.51) and ventral tegmental area (p = 0.006, d = 0.50). Follow-up analyses indicated that more severe lifetime symptoms (t = −2.72, p = 0.009) and longer illness duration (t = −2.22, p = 0.03) related to lower neuromelanin-MRI signal. Despite significant symptom reduction with therapy (p < 0.001, d = 1.44), neither baseline nor change in neuromelanin-MRI signal associated with symptom improvement. Current results provide the first demonstration of the utility of neuromelanin-MRI in pediatric psychiatry, specifically highlighting in vivo evidence for midbrain dopamine alterations in treatment-seeking youth with OCD. Neuromelanin-MRI likely indexes accumulating alterations over time, herein, implicating dopamine hyperactivity in OCD. Given evidence of increased neuromelanin signal in pediatric OCD but negative association with symptom severity, additional work is needed to parse potential longitudinal or compensatory mechanisms. Future studies should explore the utility of neuromelanin-MRI biomarkers to identify early risk prior to onset, parse OCD subtypes or symptom heterogeneity, and explore prediction of pharmacotherapy response.
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影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
影响因子：
25.8
作者：
Horga, Guillermo;Wengler, Kenneth;Cassidy, Clifford M.
通讯作者：
Cassidy, Clifford M.
影响因子：
14.5
作者：
Biondetti, Emma;Gaurav, Rahul;Lehericy, Stephane
通讯作者：
Lehericy, Stephane
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
DOI：
10.1038/nrn.2015.8
发表时间：
2016-01
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Kalueff AV;Stewart AM;Song C;Berridge KC;Graybiel AM;Fentress JC
通讯作者：
Fentress JC