Correlation between clinical and MRI assessment of depth of invasion in oral tongue squamous cell carcinoma.
Correlation between clinical and MRI assessment of depth of invasion in oral tongue squamous cell carcinoma.
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DOI：
10.1186/s40463-016-0172-0
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发表时间：
2016-11-22
期刊：
影响因子：
--
通讯作者：
Irish JC
中科院分区：
文献类型：
--
作者：
Alsaffar HA;Goldstein DP;King EV;de Almeida JR;Brown DH;Gilbert RW;Gullane PJ;Espin-Garcia O;Xu W;Irish JC
颈部转移是口腔鳞状细胞癌最重要的预后因素。除T分期外，浸润深度已被用作显微镜下颈部转移的高度可预测因素，尽管在确切的浸润深度分界点上存在争议。侵犯的深度可以通过临床和放射学来确定。然而，没有标准的工具来确定术前浸润深度。虽然MRI被广泛用于头颈部疾病的分期，但其在深度评估中的实用性尚未得到正式评估。比较术前临床和影像学对舌鳞癌的深度评估。为了比较浅表（<5 mm）与深部浸润肿瘤（≥5 mm）之间的临床和放射学准确性，该前瞻性研究使用了提交给多伦多大学健康网络（UHN）的连续活检证实的口腔舌浸润性SCC。术前确定临床检查、放射学扫描和适当的分期。回顾术后标准病理报告，以确定肿瘤标本的浸润深度。72个肿瘤样本可用于分析，53名患者被纳入。对于所有肿瘤，临床深度（r = 0.779; p < 0.001）和放射学深度（r =0.907; p <0.001）与病理学深度相关性良好，放射学深度相关性稍好。临床深度与X线片深度也有很好的相关性（r = 0.731; p < 0.001）。相比之下，对于浅表肿瘤（病理测量小于5 mm），临床（r = 0.333，p = 0.34）和放射学检查（r =-0.211; p = 0.56）均与病理浸润深度无关。这是第一项评价口腔癌肿瘤厚度临床评估与放射学解释的研究。深部肿瘤（≥5 mm）的病理学、放射学和临床测量结果之间存在很强的相关性。浅表肿瘤（<5 mm）临床及影像学检查与病理厚度相关性低。
Neck metastasis is the most important prognostic factor in oral cavity squamous cell carcinomas (SCC). Apart from the T- stage, depth of invasion has been used as a highly predictable factor for microscopic neck metastasis, despite the controversy on the exact depth cut off point. Depth of invasion can be determined clinically and radio logically. However, there is no standard tool to determine depth of invasion preoperatively. Although MRI is used widely to stage the head and neck disease, its utility in depth evaluation has not formally been assessed. To compare preoperative clinical and radiological depth evaluation in oral tongue SCC using the standard pathological depth. To compare clinical and radiological accuracy between superficial (<5 mm) vs. deep invaded tumor (≥5 mm) This prospective study used consecutive biopsy-proven oral tongue invasive SCC that presented to the University health network (UHN), Toronto. Clinical examination, radiological scan and appropriate staging were determined preoperatively. Standard pathology reports postoperatively were reviewed to determine the depth of invasion from the tumor specimen. 72 tumour samples were available for analysis and 53 patients were included. For all tumors, both clinical depth (r = 0.779; p < 0.001) and radiographic depth (r =0.907; p <0.001) correlated well with pathological depth, with radiographic depth correlating slightly better. Clinical depth also correlated well with radiographic depth (r = 0.731; p < 0.001). By contrast, for superficial tumors (less than 5 mm on pathological measurement) neither clinical (r = 0.333, p = 0.34) nor radiographic examination (r = − 0.211; p = 0.56) correlated with pathological depth of invasion. This is the first study evaluating the clinical assessment of tumor thickness in comparison to radiographic interpretation in oral cavity cancer. There are strong correlations between pathological, radiological, and clinical measurements in deep tumors (≥5 mm). In superficial tumors (<5 mm), clinical and radiological examination had low correlation with pathological thickness.
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影响因子：
45.3
作者：
Patel, Sagar C.;Carpenter, William R.;Chera, Bhishamjit S.
通讯作者：
Chera, Bhishamjit S.
影响因子：
2.6
作者：
Mayland, MK;Sessions, DG;Lenox, J
通讯作者：
Lenox, J
影响因子：
18.6
作者：
Johnson, Newell W.;Jayasekara, Prasanna;Amarasinghe, A. A. Hemantha K.
通讯作者：
Amarasinghe, A. A. Hemantha K.
影响因子：
2.9
作者：
Sagheb K;Sagheb K;Rahimi-Nedjat R;Taylor K;Al-Nawas B;Walter C
通讯作者：
Walter C
影响因子：
5.9
作者：
Preda, Lorenzo;Chiesa, Fausto;Bellomi, Massimo
通讯作者：
Bellomi, Massimo