Inducible genetic lineage tracing of cortical hem derived Cajal-Retzius cells reveals novel properties.
Inducible genetic lineage tracing of cortical hem derived Cajal-Retzius cells reveals novel properties.
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皮质 Hem 衍生的 Cajal-Retzius 细胞的诱导遗传谱系追踪揭示了新特性
DOI：
10.1371/journal.pone.0028653
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhao C
中科院分区：
文献类型：
--
作者：
Gu X;Liu B;Wu X;Yan Y;Zhang Y;Wei Y;Pleasure SJ;Zhao C
在皮质发育过程中，Cajal-Retzius（CR）细胞是最早出生的神经元亚类之一。这些神秘的神经元通过表达细胞外蛋白，reelin，在皮质发育中发挥重要作用。CR细胞起源于端脑内的离散来源，包括苍白球-苍白球下边界和苍白球内侧（皮质边缘）区域。综合证据表明，来自不同来源的CR细胞可能具有不同的分布和功能。通过使用诱导型Cre转基因小鼠工具Frizzled 10-CreER™追踪源自皮质hem的CR细胞，我们检查了皮质发育期间hem衍生的CR细胞的特定性质。我们的研究结果表明，为以后生产CR细胞从hem的祖细胞区可以具体标记早在胚胎第6.5天（E6.5），前神经期。此外，使用我们的Cre系，我们发现一些hem衍生的CR细胞沿着海马伞放射状胶质细胞支架迁移，这也是来自皮质hem，并优先定居在海马边缘区，这表明hem衍生的CR细胞在海马发育中的特定作用。
During cortical development, Cajal-Retzius (CR) cells are among the earliest-born subclasses of neurons. These enigmatic neurons play an important role in cortical development through their expression of the extracellular protein, reelin. CR cells arise from discrete sources within the telencephalon, including the pallial-subpallial border and the medial (cortical hem) regions of the pallium. Combined evidence suggests that CR cells derived from distinct origins may have different distributions and functions. By tracing CR cells derived from the cortical hem using the inducible Cre transgenic mouse tool, Frizzled 10-CreER™, we examined the specific properties of hem-derived CR cells during cortical development. Our results show that the progenitor zone for later production of CR cells from the hem can be specifically marked as early as embryonic day 6.5 (E6.5), a pre-neural period. Moreover, using our Cre line, we found that some hem-derived CR cells migrated out along the fimbrial radial glial scaffold, which was also derived from the cortical hem, and preferentially settled in the hippocampal marginal zone, which indicated specific roles for hem-derived CR cells in hippocampal development.
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