Association between exposure to HSV1 and cognitive functioning in a general population of adolescents. The TRAILS study.
Association between exposure to HSV1 and cognitive functioning in a general population of adolescents. The TRAILS study.
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DOI：
10.1371/journal.pone.0101549
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Schoevers RA
中科院分区：
文献类型：
--
作者：
Jonker I;Klein HC;Duivis HE;Yolken RH;Rosmalen JG;Schoevers RA
不同的疱疹病毒感染与精神病患者和健康成人的认知功能有关。这项研究的目的是找出是否不同的疱疹病毒抗体与一般青少年人群的认知功能的前瞻性相关。本研究在TRAILS中进行，这是一个大型前瞻性一般人群队列（N = 1084，54%为女性，平均年龄16.2岁（SD 0.6））。 在16岁时，在高敏C反应蛋白（hsCRP）旁边测量针对HSV 1，HSV 2，CMV和EBV的免疫球蛋白G抗体。两年后，即时记忆和执行功能进行了评估，使用15个字的任务和自我命令指向任务。采用自举法进行多元线性回归分析，以研究病毒感染与认知功能之间的关系，调整性别，社会经济地位，种族和大麻使用。HSV 1抗体的存在与记忆功能相关（（B = −0.272，95% CI = −0.556至−0.016，p = 0.047）），而与执行功能的相关性未达到统计学显著性（B = 0.560，95% CI为−0.053至1.184，p = 0.075）。 HSV 1抗体水平与记忆功能（B = −0.160，95% CI = −0.280至−0.039，p = 0.014）和执行功能（B = 0.296，95% CI = 0.011至0.578，p = 0.046）相关。 其他疱疹病毒和hsCRP与认知功能无关。在一个大的青少年队列中，HSV 1抗体的存在和水平与认知能力降低前瞻性相关。
Infections with different herpes viruses have been associated with cognitive functioning in psychiatric patients and healthy adults. The aim of this study was to find out whether antibodies to different herpes viruses are prospectively associated with cognitive functioning in a general adolescent population. This study was performed in TRAILS, a large prospective general population cohort (N = 1084, 54% female, mean age 16.2 years (SD 0.6)). At age 16, immunoglobulin G antibodies against HSV1, HSV2, CMV and EBV were measured next to high sensitive C-Reactive Protein (hsCRP). Two years later, immediate memory and executive functioning were assessed using the 15 words task and the self ordered pointing task. Multiple linear regression analysis with bootstrapping was performed to study the association between viral infections and cognitive function, adjusting for gender, socioeconomic status, ethnicity, and cannabis use. Presence of HSV1 antibodies was associated with memory function ((B = −0.272, 95% CI = −0.556 to −0.016, p = 0.047)), while the association with executive functioning did not reach statistical significance (B = 0.560, 95% CI is −0.053 to 1.184, p = 0.075). The level of HSV1 antibodies was associated with both memory function (B = −0.160, 95% CI = −0.280 to −0.039, p = 0.014) and executive functioning (B = 0.296, 95% CI = 0.011 to 0.578, p = 0.046). Other herpes viruses and hsCRP were not associated with cognitive functioning. Both presence and level of HSV1 antibodies are prospectively associated with reduced cognitive performance in a large cohort of adolescents.
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DOI：
10.1016/j.jaac.2013.07.008
发表时间：
2013-10
影响因子：
13.3
作者：
Ho TC;Wu J;Shin DD;Liu TT;Tapert SF;Yang G;Connolly CG;Frank GK;Max JE;Wolkowitz O;Eisendrath S;Hoeft F;Banerjee D;Hood K;Hendren RL;Paulus MP;Simmons AN;Yang TT
通讯作者：
Yang TT
影响因子：
7.7
作者：
Huisman, Martijn;Oldehinkel, Albertine J.;Ormel, Johan
通讯作者：
Ormel, Johan
影响因子：
4.4
作者：
Amone-P'Olak, Kennedy;Burger, Huibert;Oldehinkel, Albertine J.
通讯作者：
Oldehinkel, Albertine J.
影响因子：
3.3
作者：
Cabral, GA;Pettit, DAD
通讯作者：
Pettit, DAD
影响因子：
4.5
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
通讯作者：
Yolken, Robert